Collagenous colitis

Unlabeled Uses Treatment of ankylosing spondylitis, collagenous colitis, Crohn s disease, psoriasis, psoriatic arthritis... 

Budesonide for collagenous colitis caused Cushing s syndrome in a patient with chronic renal insufficiency taking amiodarone for paroxysmal atrial fibrillation (477). 

Taha, Y., et al. 2001. Evidence of local eosinophil activation and altered mucosal permeability in collagenous colitis. Dig Dis Sci 46 888. 

This condition presents with diarrhoea the colonic mucosa is macroscopically normal but histologically shows either lymphocytic infiltration of the mucosa (lymphocytic colitis) or subendothelial fibrosis (collagenous colitis). Treatment with aminosalicylate induces remission in about 50% and corticosteroid may also be needed. 

Bismuth salts are still in use. Tripotassium dicitrato-bismuthate and bicitropeptide (a bismuth-peptide complex) are used in the eradication of Helicobacter pylori in combination with antibiotics (SEDA-21,233) (1 ), and ranitidine bismuth citrate is used to treat peptic ulcer (5). Bismuth salicylates are used in other intestinal diseases, such as microscopic colitis (6,7) and collagenous colitis (8). Bismuth subnitrate plus iodoform is used to pack surgical cavities. Bismuth oxide and bismuth subgallate are found in some topical formulations that are used for treating hemorrhoids. Bismuth is also used topically as a bacteriostatic. 

Schiller LR. Microscopic colitis syndrome lymphocytic cohtis and collagenous colitis. Semin Gastrointest Dis 1999 10(4) 145-55. 

Amaro R, Poniecka A, Rogers AI. Collagenous colitis treated successfully with bismuth subsahcylate. Dig Dis Sci 2000 45(7) 1447-50. 

Fiedler LM, George J, Sachar DB, et al Treatment responses in collagenous colitis. Ant J Gastroenterol... 

All colonic biopsies showed erosions with severe infiltration by inflammatory cells. Masson s trichrome staining identified subepithelial collagen bands as thick as 25 pm in every specimen, consistent with collagenous colitis. Lansoprazole was withdrawn, and within a few days the watery diarrhea disappeared. Colonoscopy 2 months later showed a reduction in the number of red spots. Biopsies from the cecum, ascending, transverse, and descending colons, and rectum, showed no collagen bands. 

Microscopic lymphocytic and collagenous colitis can occur with other proton pump inhibitors, although they are more frequent with lansoprazole [48 ]. 

Onodera H, Tateno H. Linear mucosal defects a characteristic endoscopic finding of lansoprazole-associated collagenous colitis. Endoscopy 2010 42(Suppl. 2) E9-E10. 

Gastrointestinal Fifteen patients diagnosed with collagenous colitis between 1999 and 2011 in a Japanese hospital were studied. Two cases were associated with use of meloxicam (onset several months or several years after drug use), withdrawal of meloxicam resulted in clinical improvement of symptoms within 8 and 7 days [42 ]. 

Nervous system A 56-year-old woman, presented with progressive confusion and difficulty in concentrating that had been occurring for the past 2 weeks. She had a medical history of collagenous colitis, irritable bowel syndrome, hypothyroidism, hypoparathyroidism, hypertension, gastro-oesophageal reflux disease and depression/anxiety. These symptoms were followed by myoclonic jerks, hand fremors, gait instability and visual hallucinations. She had... 

Kitagawa T, Sato K, Yokouchi Y, Tominaga K, Ito S, Maetani 1. A case of lansoprazole-associated collagenous colitis with longitudinal ulcer. J Gastrointestin liver Dis 2013 22 9. 

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