Collaborative Drug Discovery Tuberculosis

CDD has been funded by the Bill and Melinda Gates Foundation (BMGF) which has enabled them to build strong relationships with the TB pilot labs and also build the Collaborative Drug Discovery Tuberculosis Database (CDD TB DB, accessed at http //www.collaborativedrug.com/register). We have also... 

Key words Bayesian models, Collaborative Drug Discovery Tuberculosis database, Docking, Mycobacterium tuberculosis, Quantitative structure-activity relationship, Tuberculosis... 

CDD Collaborative Drug Discovery Repository of small-molecule libraries of more than 300,000 compounds derived from patents, literature, and high-throughput screening data shared by academic and pharmaceutical laboratories tested against M. tuberculosis preliminary public antimalarial database from multiple sources on 30,000 public compounds (https //www.collaborativedrug.com/pages/public access)... 

The broad goals of Collaborative Drug Discovery (CDD) are to enable a collaborative cloud-based tool to be used to bring together neglected disease researchers and other researchers from usually separate areas, to collaborate and to share compounds and drug discovery data in the research community, which will ultimately result in long-term improvements in the research enterprise and health care delivery. This chapter briefly introduces CDD software and describes applications in antimalarial and tuberculosis research. 

Key words Collaborative Drug Discovery, Malaria, Tuberculosis, Neglected diseases... 

Collaborative drug discovery projects in the public domain normally focus on neglected tropical diseases (e.g., tuberculosis, malaria, and leishmaniasis) due to the evident medical need, the reduced competition, and associated intellectual property burden. The Medicines for Malaria Venture (MMV) [32] was the first to focus on malaria in a collaborative shion. MMV started in 1999 with initial funding (US 4 million) from the governments of Switzerland and the Netherlands, the UK Department for International Development, the World Bank, and the Rockefeller Foundation. 

Ekins S et al (2010) A collaborative database and computational models for tuberculosis drug discovery. Mol Biosyst 6 840-851... 

TB Alliance (Global Alliance for TB Drug Development) is a not-for-profit organization dedicated to the discovery and development of better, faster acting, and affordable tuberculosis drugs/regimens. It was founded in 2000 with main offices in New York and Pretoria. We are a product development partnership venture that involves collaboration with academic laboratories and major pharmaceutical companies in order to harness the power of global innovation, expertise, and... 

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