Moclobemide Citalopram

Maprotiline, Moclobemide, Mianserin, Fluoxetine (Prozac), Paroxetine, Sertraline, Fluvoxamine, Citalopram, Venlafaxin (generic IR formulation and the brand Venlafaxine XR), Mirtazapine, Flupentixol-melitracen (Deanxit), Tianeptine, Extract of St. John s Wort, Buspirone Depression and anxiety... 

Antidepressants amitriptyline, clomipramine, imipramine, moclobemide, citalopram Antipsychotics olanzapine... 

Reports are on hand relating to more recent antidepressants such as bupropion, citalopram (Fairweather ei ul., 1997), fluoxetine (Gelfin et ul.. 1998). moclobemide (Dingemanse et ul., 1998) and paroxetine (Brauer et ul.. 1995). These products, in agreement with their clinical profiles, produce fewer subjective effects and generally less sedation in healthy subjects than the older... 

A larger set of placebo-controlled studies show conclusively that imipramine is also effective for the treatment of panic disorders. Other agents shown to be effective in panic disorders include the SSRIs paroxetine, sertraline, fluvoxamine, fluoxetine and citalopram. Generally, initial treatment of moderate to severe panic disorders may require the initiation of a short course of benzodiazepines e.g. clonazepam (0.5 1 mg twice daily), and an SSRI. The patient will obtain immediate relief from panic attacks with the benzodiazepine whereas the SSRI may take 1 6 weeks to become effective. Once a patient is relieved of initial panic attacks, clonazepam should be tapered and discontinued over several weeks and SSRI therapy continued thereafter. There are no pharmacological treatments available for specific phobias, however controlled trials have shown efficacy for several agents, e.g. phenelzine, moclobemide. clonazepam, alprazolam, fluvoxamine. sertraline and paroxetine in the treatment of social phobia (Roy-Byrne and Cowlev, 2002). 

Imipramine, desipramine, amitriptyline, nortriptyline, trimipramine, clomipramine, lofepramine, amoxapine, dosulepin, maprotiline, mianserin, setiptiline, trazodone, fluvoxamine, paroxetine, milnacipram, sulpiride, tandspirone, methylpheni-date, melitracen Amitriptyline, imipramine, trimipramine, clomipramine, citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, venlafaxine, reboxetine, viloxazine, doxepin, maprotiline, mianserine, mirtazapine, moclobemide, trazodone, opipramol (and some metabolites)... 

However, the use of antidepressants in completed suicide showed an upward trend, while the use of more violent methods (gassing, hanging) fell During this time prescription of moclobemide and two SSRIs (citalopram and fluoxetine) increased, while that of tricyclics (mainly doxepin and amitriptyline) remained steady. The mean annual fatal toxicity index was highest for tricyclics, such as doxepin, trimipramine, and amitripyline, and lowest for SSRIs. 

Five fatal cases of serotonin syndrome after combined overdoses of moclobemide with citalopram and moclobemide with clomipramine have been reported (SEDA-18, 16). Several cases of this syndrome have been reported in patients taking moclobemide with drugs that potentiate serotonin function (24-31). 

Neuvonen PJ, Pohjola-Sintonen S, and Tacke U (1993) Five fatal cases of serotonin syndrome after moclobemide-citalopram or moclobemide-clomipramine overdoses (letter). Lancet 342 1419. 

Moclobemide Concurrent use with escitalopram or citalopram make cause serotonin syndrome. 

Clinically important, potentially hazardous interactions with carbidopa, citalopram, doxepin, ephedra, ephedrine, escitalopram, fluoxetine, fluvoxamine, levodopa, meperidine, moclobemide, nefazodone, oral contraceptives, paroxetine, sertraline, venlafaxine... 

There have been a few documented cases of serotonin syndrome when citalopram was combined with moclobemide. 

A few cases of fatal and rapidly developing serotonin syndrome have been reported with the combined use of citalopram and moclobemide. Clinically significant or severe interactions have not been found to date (in several well-controlled trials) with the combined use of fluoxetine, fluvoxamine, and moclobemide, nor with amitriptyline or desipramine when given with moclobemide. One case has been reported of serotonin syndrome with the combined use of moclobemide and imipramine and another of suspected serotonin syndrome when moclobemide was given with clomipramine. 

For MDD with melancholic features, paroxetine and venlafaxine are the first-line treatments. TCAs and moclobemide are the second-line treatments. Citalopram and fluoxetine are third-line treatments. 

For MDD with seasonal pattern (MDDSP), bright-light therapy is the first-line treatment. Fiuoxetine and moclobemide are second-line treatments. Bupropion, citalopram, and tranylcypromine are third-line treatments. 

Dams R, Benijts THP, Lambert WE, Van Bocxlaer JF, Van Varenbergh D, Van Peteghem C, De Leenheer AP. A fatal case of serotonin syndrome after combined moclobemide-citalopram intoxication. J/fna/roxico/(2001)25,147-51. 

Finally, we have assayed the in vivo antidepressant effect of a natural phenolic compound, frans-resveratrol, and an oxoisoaporphine derivative, 5-methoxy-7/f-dibenzo[Je,/i]quinolin-7-one, 0X0 4 (Figime 12). The antidepressant-like effect of trans-resveratrol and 0X0 4 was evaluated through a Forced Swimming Test (FST), and they were compared with reference antidepressants imipramine, desipramine, nomifensine, bupropion, nisoxetine, citalopram and moclobemide. In this sense, we evaluate 0X0 4 at 15, 30 and 45 min. affording the mayor reduction at 30 min after the administration. 

Noninterfering amitriptyline, bupropion, citalopram, clomipramine, clozapine, dox-epin, haloperidol, 2-hydroxydesipramine, 2-hydroxyimipramine, imipramine, loxapine, moclobemide, olanzapine, risperidone... 

Duvemeuil, C. de la Grandmaison, G.L. De Mazancourt, P. Alvarez, J.-C. A hi -performance liquid chromatography method with photodiode-array UV detection for therapeutic drug monitoring of the nontricyclic antidepressant drugs, Ther.Drug Monit.,2003,25,565-573. [LOD 2.5-10 ng/mL plasma fluoxetine norfluoxetine sertraline paroxetine citalopram fluvoxamine moclobemide mirtazapine milnacipran toloxatone venlafaxine viloxazine]... 

---