Chromosomes Linkage

C. Meno, Y. Ito, Y. Saijoh, Y. Matsuda, K. Ikshiro, S. Kuhara, and H. Hamada. Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2, their distinct expression domains, chromosomal linkage and direct neuraiizing activity in Xenopus embryos. Cell, 82 (5), 803-814, 1995. 

Yamamoto, K., Narukawa, J., Kadono-Okuda, K. et al. 2006. Construction of a single nucleotide polymorphism linkage map for the silkworm, Bombyx mori, based on bacterial artificial chromosome end sequences. Genetics, 173(1) 151—161. 

Lederberg s construction of a branched chromosome map on the basis of linkage analysis was mentioned in the last section. As late as the 1950s, Delbruck continued to hope that the physical order of loci on chromosomes would contradict their order as determined by linkage analysis this was supposed to show the limitation of reductionist explanation in biology.12... 

Marsh D, Neely J, Breazeale D et al. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total semm immunoglobin E concentrations. Science 1994 264 1152-1156. 

Zavattari P, Deidda E, Whalen M et al. Major factors influencing linkage disequilibrium by analysis of different chromosome regions in distinct populations demography, chromosome recombination frequency and selection. Hum Mol Genet 2000 9 2947-2957. 

Genetic linkage to nicotine dependence was examined in families from New Zealand, and regions on chromosomes 2, 4, 10, 16, 17 and 18 yielded small but positive lod scores [39]. These findings were not replicated in a study on families from the United States. All these studies were relatively small and it is probable they did not provide sufficient power to detect genes of small effect or those which influence risk in only a proportion of the families. 

Kaufman D, Xia J, Keith D, Newam D, Evans C, Lusis A. Localization of the delta opioid receptor to mouse chromosome 4 by linkage analysis. Genomics 1994 19 405-406. 

Linkage The closer two or more markers (e.g., polymorphisms) on a chromosome are together the lower is the probability that they will be separated during DNA repair or replication. Therefore, the closer they are linked together, the greater is the probability that they will be inherited together. 

Linkage map A map of the relative positions of genetic loci on a chromosome, constructed from data how often the loci are inherited together. The distance is measured in centimorgans (see also centimorgan) (cM). 

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