Recombination, chromosomal

Polymorphisms in the human genome are often not independently transmitted i.e., a polymorphism is associated with particular variants present on the same chromosome. Recombination erodes this association, but for physically close polymorphisms (e.g., within a gene), the correlation, known as LD, persists over time. 

Zavattari P, Deidda E, Whalen M et al. Major factors influencing linkage disequilibrium by analysis of different chromosome regions in distinct populations demography, chromosome recombination frequency and selection. Hum Mol Genet 2000 9 2947-2957. 

Genes may be duplicated or deleted when recombination occurs between two different genes on the two copies of the same chromosome. Recombination can occur between two regions of two different genes with some sequence homology. 

Each type of virus has different attributes, so several classes of animal viruses are being engineered as vectors to transform mammalian cells. Adenoviruses, for example, lack a mechanism for integrating DNA into a chromosome. Recombinant DNA introduced via an adenoviral vector is therefore expressed for only a short time and then destroyed. This can be useful if the objective is transient expression of a gene. 

Kipps, T.J. Herzenberg, L.A. (1986). Homologous chromosome recombination generating immunoglobulin allotype and isotype switch variants. EMBO J. 5, 263-268. 

Name derived from eleven-nineteen /ysine-rich /eukemia.The gene for ELL is the site of chromosomal recombination events frequently associated with acute myeloid leukemia. 

If the strands that will break are those that were not broken in step 1, resolution of the resulting structure generates two chromosomes recombinant for DNA flanking the region and each containing a heteroduplex region. 

Figure 4.2 Distribution of particle size index (PSI) of flours from 56 Chinese Spring (Hope-5D) chromosome recombination lines. The upper and lower histograms refer, respectively, to lines with and without the strong 15,000-MW band. (Reproduced with permission from Greenwell, P., and J. D. Schofield. 1986.

A total of 113 females and 6 males were analyzed. The former included 3 4n, 102 3n, and 8 2n females. Among the latter, 5 2n males were confirmed as the products of chromosomal recombination. Other experiments, in which genetically marked sex chromosomes were used and X rays and high-tempera-... 

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