Cimetidine Digoxin

T Pancreatic insulin release Metformin Peripheral insulin sensitivity hepatic glucose output/production i intestinal glucose absorption Dose Ist-line (naive pts), 1.25/250 mg PO daily-bid 2nd-line, 2.5/500 mg or 5/500 mg bid (max 20/2000 mg) take w/ meals, slowly T dose hold before 48 h after ionic contrast media Caution [C, -] Contra SCr >1.4 mg/dL in females or >1.5 mg/dL in males hypoxemic conditions (sepsis, recent MI) alcoholism metabolic acidosis liver Dz Disp Tabs SE HA, hypoglycemia, lactic acidosis, anorexia, N/V, rash Additional Interactions T Effects W/ amiloride, ciprofloxacin cimetidine, digoxin, miconazole, morphine, nifedipine, procainamide, quinidine, quinine, ranitidine, triamterene,... 

Quazepam (Doral) [C IV] [Sedative/Hypnotic/ Benzodiazepine] Uses Insomnia Action Benzodiazepine Dose 7.5-15 mg PO hs PRN i in elderly hqjatic failure Caution [X, /-] NA glaucoma Contra PRG, sleep apnea Disp Tabs SE Sedation, hangovCT, somnolence, resp depression Interactions T Effects W/ azole antifungals, cimetidine, digoxin, disulfiram, INH, levodopa, macrolides, neuroleptics, phenytoin, quinolones, SSRIs, verapamil, grapefruit juice, EtOH effects W/carbamazepine, rifampin, rifabutin, tobacco EMS Use caution w/ other benzodiazepines, antihistamines, opioids and verapamil, can T CNS depression concurrent EtOH and grapefruit juice use T CNS depression OD May cause profound CNS depression, confusion, bradycardia, hypotension, and altered reflexes flumazenil can be used as antidote activated charcoal may be effective... 

Side effects include dry mouth, constipation, nausea, vomiting, rash, pruritus, dizziness. It adsorbs and interferes with absorption of tetracycline, cimetidine, digoxin and phenytoin. 

Drug Interactions Cyclosporine Gemfibrozil Niacin Erythromycin Cholestyramine/Colestipol Warfarin Cimetidine Digoxin ... 

Simultaneous administration of sucralfates with other nonantacid medication should be given after an interval of at least 2 hours. Sucralfates interact with rantidine, cimetidine, digoxin, quinidine, theophylline, and warfarin. Sulfasalazine should be administered with caution with antibacterials and antineoplastics.179... 

Medications whose excretion is primarily renal and for which there is evidence of age-related reduction in renal and total body clearance include (but are not limited to) amantadine, aminoglycosides, atenolol, captopril, cimetidine, digoxin, lithium, and vancomycin. Some hepatically metabolized medications can yield active, primarily renally excreted metabolites such as iV-acetylprocainamide, normeperidine, and morphine-6-glucuronide, which can accumulate with advancing age owing to reduced renal function. 

Metoclopramide increases gastric transit time, enhancing the absorption of substances absorbed in the small intestine (e.g., ethanol, cyclosporin) and decreasing the absorption of substances absorbed in the stomach (e.g., cimetidine, digoxin). Anticholinergic drugs and dopamine-function-enhancing substances such as levodopa reduce the effectiveness of metoclopramide. Because metoclopramide releases catecholamine, it should be used cautiously with monoamine oxidase inhibitors such as tranylcypromine. Because metoclopramide inhibits plasma cholinesterase, it increases the effectiveness of succinylcholine, a skeletal muscle relaxant. 

Anastrozole does not appear to interact with aspirin, cimetidine, digoxin, oral antidiabetics or quinapril. It also appears to have no effect on cytochrome P450 enzymes, so it is unlikely to interact with drugs that are affected by enzyme inducers or inhibitors. 

No adverse interactions appear to occur with clopidogrel and alu-minium/magnesium hydroxide, atenolol, cimetidine, digoxin, food, insulin, nifedipine, oestrogens, phenobarbital, phenytoin or tolbutamide. 

Meloxicam has been shown to have interactions with the following common medications ACE inhibitors, aspirin, cholestyramine, cimetidine, digoxin, furo-semide, hthium, methotrexate, warfarin [ 1 ]. 

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