Cholesterol garlic

Garlic Allium sativum Lowers blood sugar, cholesterol, and lipids May cause abnormal blood glucose levels Increased risk of bleeding in patients taking the coumarins, salicylates, or antiplatelet drugs. 

FA092 Kamanna, V.S., and N. Chandrasekhara. Effect of garlic (Allium sativum Linn) on serum lipoproteins and lipoprotein cholesterol levels in albino rats rendered hypercholesteremic by feeding cholesterol. Lipids 1982 17(7) 483-488. 

Garlic is one of the most common botanical remedies used by patients with human immunodeficiency virus (HIV), probably because of to the antiviral claim associated with its consumption, as well as the possibility of lowering total serum cholesterol, which could counteract the common side effect of hypercholesterolemia associated with the use of antiretroviral drug regimens. 

Allium chinense Max. A. odorum L. A. sativum L. A. tuberosum Roxb. A. uliginosum G. Don Da Suan (Garlic) (bulb) Allicin, allistatin, glucominol, neo-allicin, steroidal saponins, polysaccharides, furostanol saponins, proto-isoerubosides, diallyl sulfide.33 49 438 490-510 Antibacterial, antimutagenic, anticarcinogenesis, carminative, antiarrhythmic, lower plasma cholesterol and low-density lipoproteins, prevent thrombosis, hypotensive and vessel protective effect. 

Garlic Allium sativum L Bulb of the garlic plant Decrease cholesterol and other plasma lipids anti-inflammatory antimicrobial antioxidant other effects... 

It was demonstrated previously that allicin extracted from garlic had a lipid-lowering effect on long-term feeding to healthy rats. These studies reported a significant decrease in total serum lipids, phospholipids, and cholesterol in the animals fed allicin compared to control animals. 

The cholesterol-lowering effect of garlic was also seen in rabbits that were fed 2 g choles-terol/day for 16 weeks. A dose-dependent reduction of serum cholesterol in garlic-fed rats was observed in these experiments. 

A study carried out in the U.S. showed a 56% decrease in serum total lipid radioactivity in rats fed the equivalent of 5 g of fresh garlic bulbs/d for 7 d. Rats fed an experimental diet containing cholesterol were treated either with intraperitoneal injections of C-14 labeled acetate or a diet containing C-14 sucrose. 

In summary, the consumption of garlic appears to reduce serum cholesterol in experimental animals in a dose-dependent fashion. This may be due to decreased synthesis or increased excretion of cholesterol through the intestinal tract. It has been reported that garlic consumption increases high-density lipoprotein (HDL) levels, which may help to remove excess cholesterol from arterial tissue. 

Garlic. Fresh and dried garlic are used to lower cholesterol and to treat the common cold, coughs, bronchitis, fever, and inflammation of the mouth. Garlic appears to be effective for these uses. Twenty-five clinical trials involving more than 1,000 patients... 

In vitro, allicin and related compounds inhibit HMG-CoA reductase, which is involved in cholesterol biosynthesis (see Chapter 35 Agents Used in Hyperlipidemia). Several clinical trials have investigated the lipid-lowering potential of garlic. Some have shown significant reductions in cholesterol and others no effect. The most recent meta-analysis suggested a minor (5%) reduction of total cholesterol that was insignificant when dietary controls were in place. 

Clinical trials report antiplatelet effects following garlic ingestion and mixed effects on fibrinolytic activity. These effects in combination with antioxidant effects and reductions in total cholesterol may be beneficial in patients with atherosclerosis. In preliminary trials involving atherosclerotic patients, significant reductions in plaque volume were observed for patients taking garlic versus placebo. 

Chi, M.S. 1982. Effect of garlic products on lipid metabolism in cholesterol-fed rats. Proc. Soc. Exp. Biol. Med. 171, 174-178. 

Gebhardt, R. and Beck, H. 1996. Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte culture. Lipids 31, 1269-1276. Gehm, B.D., McAndrews, J.M., Chien, P.Y., and Jameson, J.L. 1997. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for estrogen receptor. Proc. Natl Acad. Sci. 94, 14138-14143. 

Jain, R.C. 1975. Onion and garlic an experimental cholesterol atherosclerosis in rabbits. Artery 1, 115-125. 

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