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Cholesterol functions

Here cholesterol forms the hydrophobic tail of the surfactant and is attached via a spacer to a hydrophilic pyridinium sulfate ester head. The effect of molecular imprinting in these particles was elegantly demonstrated by an immunoprecipita-tion experiment, in which a,co-cholesterol-functionalized poly(ethylene oxide) was mixed with a suspension of the imprinted particles which led to bridging flocculation and precipitation. [Pg.251]

Cholesterol functions in the body as a precursor for the synthesis of bile acids in liver, which are secreted into the gut to aid in the digestion and absorption of fat in the diet. Cholesterol is also a precursor for the synthesis of steroid hormones such as progesterone and estrogen. [Pg.16]

Cholesterol was isolated m the eighteenth century but its structure is so complex that Its correct constitution was not determined until 1932 and its stereochemistry not verified until 1955 Steroids are characterized by the tetracyclic ring system shown m Figure 26 9a As shown m Figure 26 9b cholesterol contains this tetracyclic skeleton modified to include an alcohol function at C 3 a double bond at C 5 methyl groups at C 10 and C 13 and a C Hn side chain at C 17 Isoprene units may be discerned m var lous portions of the cholesterol molecule but the overall correspondence with the iso prene rule is far from perfect Indeed cholesterol has only 27 carbon atoms three too few for It to be classed as a tnterpene... [Pg.1093]

As we have seen in this chapter steroids have a number of functions in human physiology Cholesterol is a component part of cell mem branes and is found in large amounts in the brain Derivatives of cholic acid assist the digestion of fats in the small intestine Cortisone and its derivatives are involved in maintaining the electrolyte balance in body fluids The sex hormones responsible for mascu line and feminine characteristics as well as numerous aspects of pregnancy from conception to birth are steroids... [Pg.1099]

In milk fat, cholesterol is associated with Hpoproteins in the milk fat globule. It is also a component of animal membranes and controls rigidity and permeabihty of the membranes. Cholesterol has interesting surface properties and can occur in Hquid crystalline forms. Plants contain sterols such as P-sitosterol [83-46-5] (4b) or stigmasterol [83-48-7] (4c). Their functions in plant metaboHsm are not yet well understood. Analysis of sterols has proven useful for detection of adulteration of edible fats (9). [Pg.124]

Unfortunately, excess consumption of fatty foods has been correlated with serious human disease conditions. Effects on cardiovascular disease (95), cancer (96), and function of the immune system (97) have been shown. Numerous studies have been conducted to determine the effects of saturated, monounsaturated, and polyunsaturated fatty acids on semm cholesterol and more recently high density Hpoprotein (HDL) and low density Hpoprotein... [Pg.134]

Bde salts, cholesterol, phosphoHpids, and other minor components are secreted by the Hver. Bile salts serve three significant physiological functions. The hydrophilic carboxylate group, which is attached via an alkyl chain to the hydrophobic steroid skeleton, allows the bile salts to form water-soluble micelles with cholesterol and phosphoHpids in the bile. These micelles assist in the solvation of cholesterol. By solvating cholesterol, bile salts contribute to the homeostatic regulation of the amount of cholesterol in the whole body. Bile salts are also necessary for the intestinal absorption of dietary fats and fat-soluble vitamins (24—26). [Pg.415]

The possibility that vitamins might have physiological functions beyond the prevention of deficiency diseases was first recognized in 1955 with the finding (8) that niacin can affect semm cholesterol levels in humans. An explosion of research (9—11) in the intervening years has been aimed at estabUshing optimal vitamin levels and anticipating the health consequences. [Pg.4]

Biochemical Functions. Ascorbic acid has various biochemical functions, involving, for example, coUagen synthesis, immune function, dmg metabohsm, folate metaboHsm, cholesterol cataboHsm, iron metaboHsm, and carnitine biosynthesis. Clear-cut evidence for its biochemical role is available only with respect to coUagen biosynthesis (hydroxylation of prolin and lysine). In addition, ascorbic acid can act as a reducing agent and as an effective antioxidant. Ascorbic acid also interferes with nitrosamine formation by reacting direcdy with nitrites, and consequently may potentially reduce cancer risk. [Pg.21]

L-Tyrosine metabohsm and catecholamine biosynthesis occur largely in the brain, central nervous tissue, and endocrine system, which have large pools of L-ascorbic acid (128). Catecholamine, a neurotransmitter, is the precursor in the formation of dopamine, which is converted to noradrenaline and adrenaline. The precise role of ascorbic acid has not been completely understood. Ascorbic acid has important biochemical functions with various hydroxylase enzymes in steroid, dmg, andhpid metabohsm. The cytochrome P-450 oxidase catalyzes the conversion of cholesterol to bUe acids and the detoxification process of aromatic dmgs and other xenobiotics, eg, carcinogens, poUutants, and pesticides, in the body (129). The effects of L-ascorbic acid on histamine metabohsm related to scurvy and anaphylactic shock have been investigated (130). Another ceUular reaction involving ascorbic acid is the conversion of folate to tetrahydrofolate. Ascorbic acid has many biochemical functions which affect the immune system of the body (131). [Pg.21]

There are other ways in which the lateral organization (and asymmetry) of lipids in biological membranes can be altered. Eor example, cholesterol can intercalate between the phospholipid fatty acid chains, its polar hydroxyl group associated with the polar head groups. In this manner, patches of cholesterol and phospholipids can form in an otherwise homogeneous sea of pure phospholipid. This lateral asymmetry can in turn affect the function of membrane proteins and enzymes. The lateral distribution of lipids in a membrane can also be affected by proteins in the membrane. Certain integral membrane proteins prefer associations with specific lipids. Proteins may select unsaturated lipid chains over saturated chains or may prefer a specific head group over others. [Pg.266]

High-density lipoproteins (HDL) have much longer life spans in the body (5 to 6 days) than other lipoproteins. Newly formed HDL contains virtually no cholesterol ester. However, over time, cholesterol esters are accumulated through the action of lecithin cholesterol acyltransferase (LCAT), a 59-kD glycoprotein associated with HDLs. Another associated protein, cholesterol ester transfer protein, transfers some of these esters to VLDL and LDL. Alternatively, HDLs function to return cholesterol and cholesterol esters to the liver. This latter process apparently explains the correlation between high HDL levels and reduced risk of cardiovascular disease. (High LDL levels, on the other hand, are correlated with an increased risk of coronary artery and cardiovascular disease.)... [Pg.845]

Therapeutic Function Solubilizer for cholesterol gallstones Chemical Name 3,7-Dihydroxycholan-24-oic acid Common Name Chenodeoxycholic acid chenic acid Structural Formula ... [Pg.293]

Therapeutic Function Cholesterol-reducing agent Chemical Name 2,2 -(decamethylenedithio)diethanol Common Name -... [Pg.1475]

The cholesterol-lowering agents called statins, such as simvastatin (Zocor) and pravastatin (Pravachol), are among the most widely prescribed drugs in the world. Identify the functional groups in both, and tell how the two substances differ. [Pg.105]

Generally speaking we consider that most micro-organisms live and grow in aqueous environments, and that the cytoplasm within cells in which enzymes function is also aqueous. On die other hand, most lipids are only sparingly soluble in aqueous media. Cholesterol, for example, has a solubility of less than 2 mg l 1 (equivalent to a concentration of less than 5 pmol l 1). Even at much lower concentrations (25-40 nmol l 1) it tends to aggregate into micelles. There is, therefore, a general problem of how to supply lipid substrates at sufficient concentration to produce reaction kinetics that are appropriate for industrial purposes. [Pg.337]


See other pages where Cholesterol functions is mentioned: [Pg.94]    [Pg.94]    [Pg.1100]    [Pg.120]    [Pg.104]    [Pg.266]    [Pg.415]    [Pg.420]    [Pg.46]    [Pg.63]    [Pg.68]    [Pg.256]    [Pg.465]    [Pg.6]    [Pg.63]    [Pg.124]    [Pg.468]    [Pg.119]    [Pg.227]    [Pg.1030]    [Pg.1100]    [Pg.254]    [Pg.255]    [Pg.586]    [Pg.842]    [Pg.845]    [Pg.847]    [Pg.364]    [Pg.1071]    [Pg.1375]    [Pg.169]    [Pg.190]    [Pg.351]    [Pg.227]   
See also in sourсe #XX -- [ Pg.333 ]

See also in sourсe #XX -- [ Pg.208 ]

See also in sourсe #XX -- [ Pg.85 ]




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