Chitosan-heparin

The chitosan-heparin polyelectrolyte complex was covalently immobilized onto the surface of polyacrylonitrile membrane. The immobilization caused the water contact angle to decrease, thereby indicating an increase in hy-... 

Chitin and chitosan derivatives have also been studied as blood compatible materials both in vivo and in vitro [520], Anticoagulant activity was greatest with O sulfated N acetyl chitosan, followed by N,0 sulfated chitosan, heparin, and finally sulfated N acetyl chitosan. The lipolytic activity was greatest for N,0 sulfated chitosan followed by heparin. The generally poor performance of chitosan was attributed to polyelectrolyte complexes with free amino groups present on the membrane surface. The O sulfate or acidic group at the 6 position in the hexosamine moiety was identified as the main active site for anticoagulant activity. 

PCL membranes modified by deposition of chitosan/heparin multilayer via the electrostatic self-assembly method... 

Macroscopically homogeneous chitosan/heparin blended suspension fabricated into composite films and porous scaffolds by an optimized procedure... 

Chitosan/heparin deposition could Liu et al. reduce platelet adhesion and [127]... 

Chitosan/heparin composite matrices He et al. are promising candidates for blood- [130]... 

Sun F, Pang X, Zhitomirsky I (2009) Electrophoretic deposition of composite hydroxyapa-tite-chitosan-heparin coatings. J Mater Process Technol 209(3) 1597... 

Couto DS, Alves NM, Mano IF (2009) Nanostructured multilayer coatings combining chitosan with bioactive glass nanoparticles. J Nanosci Nanotech 9 1741-1748 Dong P et al (2009) Biocompatibility of chitosan/heparin multilayer coalings on NiTi. Mater Sci Forum 610-613 1179-1182... 

Meng S et al (2009) The effect of a layer-by-layer chitosan-heparin coating on the endothelialization and coagulation properties of a coronary stent system. Biomaterials 30 2276-2283... 

D.-K. Kweon, S.-B. Song, Y.-Y. Park, Preparation of water-soluble chitosan/heparin complex and its application as wound healing accelerator, Biomaterials 24 (2003) 1595-1601. 

Zhu A, Zhang M, Wu J et al (2002) Covalent immobilization of chitosan/heparin complex with a photosensitive hetmo-brfunctional ctosslinking reagent on PLA surface. Biomaterials 23(23) 4657-4665... 

Chitosan-heparin polyelectrolyte complex nanoparticles Protein delivery [236]... 

Boddohi S, Moore N, Johnson PA et al (2009) Polysaccharide-based polyelectrolyte complex nanoparticles from chitosan, heparin, and hyaluronan. Biomacromolecules 10 1402-1409... 

The catheters were inplanted for 30 min in carotid and femoral arteries. I-Fibrinogen was injected prior to implantation the radioactivity of the entire catheter and extruded thrombus was determined by y-ray spectrometry. Table I presents the data on chitosan--heparin coated polyethylene catheters. The tridodecyl methylammonium chloride-heparin surface performs poorly in comparison to the chitosan--heparin cyanoborohydride surface. 

Chitosan-heparin coated polymers display excellent thrombo-resistance properties. The lifetime of the thromboresistance can be extended by covalently binding the heparin to chitosan with the aid of sodium cyanoborohydride. This surface treatment is useful for biomedical applications requiring blood compatibility for periods as long as four days. 

Haddad, Chitosan-heparin as a thromboresistant surface. in "Proc. Second Inti. Conference on Chitin Chitosan", S. Hirano and S. Tokura (Eds.), Japan Society for Chitin, Sapporo, Hokkaido, Japan (1982). 

Yuan W, Fu J, Su K, Ji J. Self-assembled chitosan/heparin multilayer film as a novel template for in situ synthesis of silver nanoparticles. CoUoids Surf B Biointerfaces. 2010 76(2) 549-55. 

As well as those based on chitin/chitosan, heparin, hyaluronan, xylan, glucoman-nan, pectin, xyloglucan, arabinan, starch, carrageenan, alginate, galactan as one of the components in combination with other polysaccharides. 

Chitosan-alginate PECs show good compatibility in vitro with the mouse/ human fibroblasts, osteoblasts, and chondrocytes [129]. The chondrocytes on chitosan tend to form a monolayer, a possible marker of chondrocyte dedifferentiation and fibroblastic phenotype [130]. In contrast, the chondrocytes on chitosan-alginate PECs materials form much larger cell clusters. And cell proliferation on chitosan-alginate scaffolds is found to be faster than that on a pure chitosan scaffold [131]. Kratz et al. [132]. found that the chitosan/heparin PEC can stimulate wound healing in human skin. Moreover, the chitosan/heparin complex... 

Almodovar, J., Mower, J., Baneijee, A., Sarkar, A.K., Ehrhart, N.P., Kipper, M.J. Chitosan-heparin polyelectrolyte multilayers on cortical bone Periosteum-mimetic, cytophilic, antibacterial coatings. Biotech. Bioeng. 110, 609-618 (2013)... 

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