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Chitosan biomedical applications

Keywords Chitosan, modification of chitosan, biomedical applications... [Pg.129]

Superparamagnetic iron oxide NPs encapsulated within chitosan Biomedical applications [213]... [Pg.79]

Chitosan has found many biomedical applications, including tissue engineering approaches. Enzymes such as chitosanase and lysozyme can degrade chitosan. However, chitosan is easily soluble in the presence of acid, and generally insoluble in neutral conditions as well as in most organic solvents due to the existence of amino groups and the high crystallinity. Therefore, many derivatives have been reported to enhance the solubility and processability of this polymer. [Pg.145]

This chapter focuses and reviews on the characteristics and biomedical application of chitosan and collagen from marine products and advantages and disadvantages of regeneration medicine. The understanding of the production processes of chitosan and collagen and the conformation of these biomaterials are indispensable for promoting the theoretical and practical availability. The initial inflammatory reactions associated with chitosan application to... [Pg.107]

Berger J, Reist M, Mayer JM, Felt O, Peppas NA, Gurny R. Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications. European Journal of Pharmaceutics and Biopharmaceutics 2004, 57, 19-34. [Pg.238]

Alternate anti-vs procoagulant activity of human whole blood on a LbL assembly between chitosan and dextran sulfate has been achieved [149,150]. Furthermore, the technique permits the formation of biodegradable nanostructures with nanometer-order thickness on surfaces, which is an important requirement for biomedical applications. The alternating enzymatic hydrolysis of a LbL assembly formed from chitosan and dextran sulfate by chitosanase was demonstrated via measurements with a quartz crystal microbalance (QCM) [151]. The hydrolysis of the assembly was clearly dependent on the surface component. The hydrolysis of the assembly with the dextran sulfate surface was saturated within 10 min and was much faster than the hydrolysis of the assembly with the chitosan surface, although chitosanase can hydrolyse chitosan (Fig. 14). [Pg.224]

In their further studies on chitosan for biomedical applications, Lee et al. [133] reported a procedure for preparing semi-IPN polymer network hydrogels composed of (3-chitosan and PEG diacrylate macromer, by following a similar procedure to that discussed above. The crystallinity as well as thermal and mechanical properties of gels were reported [133]. Reports on the drug release behavior of the gels are not available. [Pg.68]

Several studies were devoted to EPD of hydroxyapatite coatings reinforced with either CNTs (Kaya, 2008 Lin et al., 2008 Zhang et al., 2011), chitosan (Mah-moodi et al., 2013) or alumina (Wang, Ni and Huang, 2008). Other ceramics of importance for biomedical applications such as alumina (Salman, Jassim and Al-Zubaydi, 2011) and zirconia (Ananth et al., 2013) were deposited by EPD onto Ti alloy surfaces. [Pg.156]

Hyaluronic acid is a linear polysaccharide formed from disaccharide units containing N-acetyl-D-glucosamine and glucuronic acid. Since it is present in almost all biological fluids and tissues, hyaluronic acid-based materials are very useful in biomedical applications. After cellulose, chitin is the second most abundant natural polysaccharide resource on earth. Chitin and its de-acetylated derivative chitosan are natural polymers composed of N-acetylglucosamine and glucosamine. Both chitin and chitosan have excellent properties such as biodegradability, biocompatibility, non-toxicity, hemostatic activity and antimicrobial activity. Chitin and its derivatives are widely used in various fields of medicine. [Pg.635]

Debasish Sahoo is a senior lecturer in the Institute of Nanobiotechnology, Cuttack, India. He has an MSc in Biotechnology and has carried out extensive research work on biomedical applications of chitosan. He recently submitted his PhD thesis to the faculty of Biotechnology, Utkal University. [Pg.642]

This paper will focus on chitosan and chitosan derivatives developed for biomedical applications. In the first section, the remarkable properties of chitosan will be exposed. The main chemical modifications used to adapt this material for biomedical applications will be reviewed. Their applications in drag delivery systems and tissue engineering will then be discussed. [Pg.20]

Chitosan and chitosan derivatives have been extensively studied for drug delivery and other biomedical applications due to (1) their biocompatibility and low toxicity, (2) their possible formulation in nanoparticles or in gels, and (3) their cationic properties. An overview of their use in biomedical applications will be given for... [Pg.28]

Chitosan has received considerable attention as a functional biopolymer for diverse pharmaceutical and biomedical applications. It is a nontoxic, biocompatible, and biodegradable polymer. Chitosans can be formulated as nanocarriers mainly by... [Pg.36]

However, for most applications, practical use of chitosan has been limited by its physicochemical properties, in particular its low solubility above pH 6.5 and the pH-dependence of the ionic interactions in the formulations. Hence, chitosan derivatives have been recently developed to widen and improve the potential biomedical applications of chitosan. [Pg.37]

The physical and mechanical properties of chitosan can be amefiorated by using graft copolymerization and crosslinking. Chitosan forms aldimines and ketimines with aldehydes and ketones, respectively. Upon hydrogenation with simple aldehydes, chitosan produces A-alkyl chitosan [60]. The physicochemical and biological properties [61] as well as conformational structures [62] of chitosan are very effective for biomedical applications. [Pg.53]

Rinki K, Dutta PK, Hunt AJ et al (2011) Chitosan aerogel exhibiting high surface area for biomedical applications preparation, characterization and antibacterial study. Int J Polym Mater Article ID 553849 (GPOM-2010-0362.R1)... [Pg.73]

Jayakumar R, Prabaharan M, Nair SV et al (2010) Novel chitin and chitosan nanofibers in biomedical applications. Biotechnol Adv 28 142-150... [Pg.74]

Radhika M, Mary B, Sehgal PK (1999) Cellular proliferation on desamidated collagen matrices. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 124 131-139 Archana D, Dutta J, Dutta PK (2010) Synthesis, characterization and bioactivity with improved antibacterial effect of chitosan-pectin-titanium dioxide ternary film for biomedical applications. Asian Chitin J 6 26... [Pg.76]

Jayakumar R et al (2010) Novel chitin and chitosan nanofibers in biomedical applications. [Pg.159]

For naturally derived polymers, chitosan commands the lead as a fast-growing material for use in pharmaceutical and biomedical applications. The development of novel chitosan-based systems and new applications can be accelerated through improved processing and pmificahon methods. [Pg.10]

Sandford, P. A. and Steinnes, A., Biomedical applications of high-purity chitosan, in Water Soluble Polymers, Vol. 467, Shalaby, S. W., Ed., ACS S5nnposium Series, Vol. 467,1991, chap. 28. [Pg.85]


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See also in sourсe #XX -- [ Pg.151 , Pg.162 ]

See also in sourсe #XX -- [ Pg.177 , Pg.178 ]




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