Chitosan-based systems

Selectivity of Pd/chitosan based systems in 1,4-butynediol hydrogenation. Catalyst... 

The chemical modifications of chitosan described are not exhaustive but clearly demonstrate their benefit for drug delivery. Similarly, besides the described improvements in delivery of genes or poorly soluble drugs and in scaffolds for tissue engineering, other improvements in the delivery of therapeutic peptide and proteins or vaccines using chitosan-based systems have also been reported. 

For naturally derived polymers, chitosan commands the lead as a fast-growing material for use in pharmaceutical and biomedical applications. The development of novel chitosan-based systems and new applications can be accelerated through improved processing and pmificahon methods. 

Advances in Processing of Chitosan-Based Systems and Clinical Relevance... 

Most of the early biomedical and pharmaceutical application of chitosan-based systems dealt with topical applications and a few controlled drug... 

Agrawal, P Strijkers, G.J. Nicolay, K. Chitosan-based systems for molecular imaging. Adv. Drug Deliv. Rev. 2010, 62 (1), 42-58. 

Sarmento, B., das Neves, J. (eds.). (2012). Chitosan-Based Systems for Biopharmaceuticals Delivery, Targeting and Polymer Therapeutics. John Wiley Sons. 

S.W. Shalaby, J.A. DuBose, M. Shalaby, Chitosan Based Systems, Absorbable and Biodegradable Polymers, vol. 6, CRC Press, Boca Raton, 2004, pp. 77-89. 

The biocompatibility of chitosan has been investigated and reported over the past several decades. A great number of studies have been performed in vitro to evaluate the biocompatibility of chitosan and chitosan-based systems using a variety of cell types such as fibroblasts [95,96], osteoblasts [97,98], chondrocytes [98], endothelial cells [34], neural cells [99], and hepatocytes [100,101]. Results have shown that chitosan is nontoxic and can support these types of cells to adhere and proliferate, which suggests that chitosan is compatible with these cell types. 

Chitosan-Based Systems as Carriers of Anticancer Drugs.272... 

CHITOSAN-BASED SYSTEMS AS CARRIERS OF ANTICANCER DRUGS... 

Area, Q. H., M. Gunbeyaz, and S. enel. 2009. Chitosan-based systems for delivery of vaccine antigens. Expert... 

Shalaby S.W., DuBose J.A., Shalahy M. 2003. Chitosan based systems. In Shalaby S.W. and Burg K.J.L. (Eds.), Absorbable and Biodegradable Polymer, pp. 77-90. Boca Raton, FL Routledge/CRC Press. 

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