Chemotaxis signal transduction

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Gegner, J.A., Graham, D.R., Roth, A.F. and Dahlquist, F.W. (1992). Assembly of an MCP receptor, CheW, and Idnase CheA complex in the bacterial chemotaxis signal transduction pathway. Cell 70, 975-982. 

Ninfa, E.G., Stock, A., Mowbray, 8. and Stock, J. (1991). Reconstitution of the bacterial chemotaxis signal transduction system from purified components. J. Biol. Chem. 266, 9764-9770. 

Shah, D.S.H., Porter, S.L., Harris, D.C., Wadhams, G.H., HambHn, P.A. and Armitage, J.P. (2000). Identification of a fourth cheY gene in Rhodobacter sphaeroides and interspecies interaction within the bacterial chemotaxis signal transduction pathway. Mol. Microbiol. 35, 101-112. 

Sourjik, V. and Schmitt, R. (1998). Phosphotransfer between GheA, GheYl, and GheY2 in the chemotaxis signal transduction chain of Rhizobium meliloti. Biochemistry 37, 2327-2335. 

Stewart, R.G. (1997). Kinetic characterization of phosphotransfer between CheA and GheY in the bacterial chemotaxis signal transduction pathway. Biochemistry 36, 2030-2040. 

Stewart, R.G., VanRruggen, R., Ellefson, D.D. and Wolfe, A.J. (1998). TNP-ATP and TNP-ADP as probes of the nucleotide binding site of CheA, the histidine protein kinase in the chemotaxis signal transduction pathway of Escherichia coli. Biochemistry 37,12 269-12 279. 

Stock, J. (1999). Sensitivity, cooperativity and gain in chemotaxis signal transduction. Trends Microbiol. 7, 1—4. 

Gosling J, Monteclaro FS, Atchison RE, et al. Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity. Proc Natl Acad Sci U S A 1997 94(10) 5061-5066. 

Eukaryotic ABC transport system Phosphotransferase system (PTS) Ion-coupled transport system Signal Transduction Two-component system Bacterial chemotaxis MAPK signaling pathway Second messenger signaling pathway Ligand-Receptor Interaction G-protein-coupled receptors Ion-channel-linked receptors Cytokine receptors Molecular Assembly Ribosome assembly Flagellar assembly Enzyme assembly... 

O Reilly M, Alpert R, Jenkinson S, Gladue RP, Foo S, Trim S, Peter B, Trevethick M, Fidock M Identification of a histamine H4 receptor on human eosinophils - role in eosinophil chemotaxis. J Recept Signal Transduct Res 2002 22 431-448. 

Methylation. A group of enzymes, referred to as the protein methyltrans-ferases, use S-adenosylmethionine to methylate certain proteins. For example, one type of methyltransferase found in E. coli and related bacteria methylates glutamate residues in membrane-bound chemoreceptors. The methyltransferase and a methylesterase are components in a methylation/demethylation process, which plays a role in a signal transduction mechanism involved in chemotaxis. (Recall that the capacity of a living cell to respond to certain environmental cues by moving toward or away from specific molecules is referred to as chemotaxis.)... 

Melendez, A.J., and Ibrahim, F.B., Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2 + signals, enzyme release, cytokine production, and chemotaxis, J Immunol, 173 (2004) 1596-1603. 

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