Chemoprevention trial

Placebo-controlled chemoprevention trial 30 mg/day carotene + 25,000 lU P-Carotene Lung cancer and total mortality + 36... 

Powles T, Eeles R, Ashley S (1998) Interim analysis of the incidence of breast cancer in the Royal Marsden Hospital tamoxifen randomizjsed chemoprevention trial. Lancet 352 98-101... 

Khuri FRL, Lee JJ, Winn RJ. Interim Analysis of Randomized Chemoprevention Trial of HNSCC. Proc Annu Meet Am Soc Clin Oncol 1999 18 A 1503. 

Egner, P.A, Stansbury, K.H., Snyder, E.P., Rogers, M.E., Hintz, P.A., and Kensler, T.W. 2000. Identification and characterization of chlorin e4 ethyl ester in sera of individuals participating in the chlorophyllin chemoprevention trial. Chem. Res. Tox. 13 900-906. 

Powles TJ, Jones AL, Ashley SE, O Brien ME, Tidy VA, Treleavan J, Cosgrove D, Nash AG, Sacks N, Baum M, McKinna JA, Davey JB. The Royal Marsden Hospital pilot tamoxifen chemoprevention trial. Breast Cancer Res Treat 1994 31(l) 73-82. 

Bresalier RS, Sandler RS, Quan H, et al. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med. 2005 352 1092-1102. 

Patterson, B. and Levander, O.A. 1997. Naturally occurring selenium compounds in cancer chemoprevention trials a workshop summary. Cancer Epidemiol. Biomark. Prevent. 6, 63-69. Patterson, B., Levander, O., Helzsouer, K., McAdam, P., Lewis, S., Taylor, P., Veillon, C., and Zech, L.A. 1989. Human selenite metabolism. A kinetic model. Am. J. Physiol. 257, R556-R567. Pavlata, L., Illek, J., and Pechova, A. 2001. Blood and tissue selenium concentrations in calves treated with inorganic or organic selenium compounds. Acta Vet. Brno 70(1), 19-26. 

Ali I, Senger D, Smith L. Angiogenesis as a potential biomarker in prostate cancer chemoprevention trials. Urology 2001 57 143-147. 

Milk fat contains small amounts of ether lipids. Synthetic ether lipids at low concentrations are potent anti-neoplastic agents. Cell culture studies showed that they inhibited cell growth, induced differentiation, promoted apoptosis and showed anti-metastatic activity. In human chemoprevention trials ether lipids have been administered parenterally. Although the ether bond is preserved when these lipids are delivered orally, no cancer chemoprevention studies have utilized dietary ether lipids (Parodi, 2004). 

Goodman GE, Omenn GS. 1992. Carotene and retinol efficacy trial Lung cancer chemoprevention trial in heavy cigarette smokers and asbestos-exposed workers. CARET Coinvestigators and Staff. Adv Exp Med Biol 320 137-40. 

A patient in a Barrett s esophagus chemoprevention trial developed a hearing deficit of 15 dB at frequencies of 250, 2000, and 3000 Hz in the right ear and a deficit... 

K. D. Burney, K. Krishnan, M. T. Ruffin, D. Zhang, and D. E. Brenner, Adherence to single daily dose of aspirin in a chemoprevention trial. An evaluation of self-report and microelectronic monitoring. Arch Fam Med 5 297-300 (1996). 

Considerable interest in preventing prostate cancer exists and several large chemoprevention trials are sponsored and ongoing by the National Cancer Institute. The first large chemoprevention trial in prostate cancer, the Prostate Cancer Prevention Trial (PCPT), began in 1993 and randomized 18,881 men older than 55 years with a low risk of prostate cancer (PSA = 3 ng/mL) to receive 5 mg finasteride daily (a 5-a-reductase inhibitor) or placebo to determine if inhibition of DHT synthesis in the prostate for a prolonged period (7 years) would lead to a decreased incidence of prostate cancer. " Finasteride is currently used in the treatment of BPH. 

Armstrong, W.B. A.R. Kennedy X.S. Wan T.H. Taylor Q.A. Nguyen J. Jensen W. Thompson W. Lagerberg EL. Meyskens. Clinical modulation of oral leukoplakia and protease activity by bowman-birk inhibitor concentrate in a phase iia chemoprevention trial. Clin. Cancer Res., 2000,... 

Daidzein and genistein have been most intensively investigated because of their high levels of occurrence in soybean, a widely used animal feedstuff and a component of traditional Asian diets consumed daily in high quantities by Japanese [10] and Chinese populations [8, 11]. The consumption of products derived from soy has, therefore, been considered as the major dietary factor contributing to the lower rates of hormone-dependent diseases, including breast, prostate, and colon cancers and coronary heart disease, in many Asian countries [12-14]. Almost 10 years after Akiyama et al. [15] first identified genistein as a tyrosine protein kinase inhibitor [15], it was entered into clinical chemoprevention trials in 1996 [16, 17], followed by formal human trials as a treatment for acute lymphoblastic leukemia and breast cancer [18-20]. 

Barnes S, Peterson TG, Coward L. Rational for the use of genistein-containing soy matrices in chemoprevention trials for breast and prostate cancer. J Cell Biochem 1995 22(suppl) 181-187. 

While the epidemiological evidence for a benefit of a range of dietary antioxidants has been corrsistently compelling, the outcome of the large-scale randomized chemoprevention trials employing antioxidant supplement preparatiorrs of vitamin C,... 

In fact, the hmitations inherent in randomized chemoprevention trials, including... 

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