Chemokines in inflammation

Proost, P., Wuyts, A., and van Damme, J. 1996. The role of chemokines in inflammation. International Journal of Clinical and Laboratory Research 26(4), 211-223. 

Foxman EF, Kunkel EJ, Butcher EC. Integrating conflicting chemotactic signals the role of memory in leukocyte navigation. J Cell Biol 1999 147 577-588. Baggiolini M, Loetscher P. Chemokines in inflammation and immunity. Immunol Today 2000 21 418-420. 

Baggiolini M, Loetscher P (2000) Chemokines in inflammation and immunity. Immunol Today 21 418-420... 

Charo IF, Ransohoff RM (2006) The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 354 610-621... 

It is well established that NF-kB signaling plays a critical role in inflammation and immunity. Understanding the mechanism of NF-kB involvement in opioid receptor activation and chemokine expression may provide a vital key to understanding this complex signaling network. However, the elucidation of molecular mechanisms following activation of the opioid receptor family could aid in the development of future therapeutics for immune system-related and inflammatory diseases, drug addiction and HIV infection. 

Chemokines and their receptors control the mobilization of naive DC precursors into the circulation in inflammation. Both DC precursor types express a common set of chemokine receptors such as CCR1, CCR5, and CXCR4,... 

Murdoch C, Finn A. Chemokine receptors and their role in inflammation and infectious diseases. Blood 2000 95(10) 3032-3043. 

Gonzalo JA, Lloyd CM, Wen D, et al. The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness. J... 

Moser B, Willimann K. Chemokines role in inflammation and immune surveillance. Ann Rheum Dis 2004 63(Suppl 2) ii84-ii9. 

Marra F. Chemokines in liver inflammation and fibrosis. Front Biosci 2002 7 dl899-dl914. 

L19. Luster, A. D., and Rothenberg, M. E., Role of the monocyte chemoattractant protein and eotaxin subfamily of chemokines in allergic inflammation. J. Leukocyte. Biol. 62, 620-633 (1997). 

There are multicellular interactions that are important in inflammatory processes and in vascular remodeling. Activated platelets induce endothelial cells to secrete chemokines and to express adhesion molecules, indicating that platelets could initiate an inflammatory (Table I) response of the vessel wall. Activated platelets promote leukocyte binding to inflamed or atherosclerotic lesions (27,28). Cell adhesion molecules (CAMs) are responsible for leukocyte-endothelium interactions. It plays a crucial role in inflammation and atherogenesis. Vascular CAM-1 (VCAM-I)and intracellular CAM-1 (ICAM-I) promote monocyte recruitment to sites of injury and constitute a critical step in inflammation and in atherosclerotic plaque development. TSP-1, a matricellular protein released in abundance from activated platelets and accumulated in sites of vascular injury, induces the expression of VCAM-1 and ICAM-1 on endothelium and significantly increases the monocyte attachment (29). 

Schroder, J. M. and Mochizuki, M. 1999. The role of chemokines in cutaneous allergic inflammation. Biol Chem 389 889-896. 

Lukacs, N. W., Stricter, R. M., Warmington, K., Lincoln P., Chensue, S. W., and Kunkel, S. L. (1997). Differential recruitment of leukocyte populations and alteration of airway hyperreactivity by C-C family chemokines in murine allergic airway inflammation. J. Immunol. 158, 4398 1404. 

Lloyd, C. M., and Gutierrez-Ramos, J. C. (1998) The role of chemokines in tissue inflammation and autoimmunity in renal diseases. Curr. Opin. Nephrol. Hypertens. 7, 281-287. 

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