Evidence That Chemokines Regulate the Pattern of Organ-Specific Metastasis

Evidence That Chemokines Regulate the Pattern of Organ-Specific Metastasis 

Marcel Dekker, Inc. 270 Madison Avenue, New York, New York 10016 

Preneoplastic to neoplastic transformation Regulation of angiogenesis Promotion of tumor cell invasion Recruitment of tumor-associated leukocytes Regulation of the pattern of organ-specific metastasis 

Studies in our laboratory have found similar results with NSCLC cell lines (unpublished observations). These findings support the notion that certain chemokine ligand(s) and their receptors orchestrate precise and preferential destination of metastatic tumor cells to specific organs. 

Devessa SS, Blot WJ, Stone BJ, Miller BA, Tarone RE, Fraumeni JF, Jr. Recent cancer trends in the United States [see comments]. J Natl Cancer Inst 1995 87 175-182. 

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VIII. EVIDENCE THAT CHEMOKINES REGULATE THE PATTERN OF ORGAN-SPECIFIC METASTASIS OF CANCER... 

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