Regulation of Chemokine Expression by STAT Proteins

Indiana University School of Medicine Indianapolis, Indiana, U.S.A. 

STAT proteins have several functional domains, including a DNA-binding domain and a Src-homology 2 (SH2) domain. The SH2 domain binds phosphorylated tyrosines on the activated receptor, thus recruiting the STAT protein to the receptor complex. STAT proteins are then substrates for the JAKs and become 

Marcel Dekker, Inc. 270 Madison Avenue. New York. New York 10016 

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