Chemicals cacodylate

The rates of hydrolysis and binding to DNA of anti-DE-I, syn-DE-I, anti-DE-II, syn-DE-II, and anti-1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydrochrysene (anti-chrysene-DE) were studied in order to relate the chemical reactivity of these dihydrodiol epoxides to their biological activities. The half-lives of the dihydrodiol epoxides in cacodylate buffer at pH 7.0 and 37°C are summarized in Table III and their relative extents of binding to DNA in Table IV. It is clear that the rates of hydrolysis of the dihydrodiol epoxides do not correlate with their DNA binding properties. 

Clean the vial and score it with a diamond scribe. Place it in a clean glass bottle, and add the water. With a glass rod, break the vial. The solution is stable if kept refrigerated and protected from light. The stock solution should be stored away from other chemicals, since osmium vapors may escape from the bottle. Alternatively, aqueous solutions of osmium tetroxide in sealed glass ampules are available commercially. Dilute them to 1-2% with O.IM cacodylate buffer for use. 

Robert Wilhelm Bunsen, 1811-1899, German chemist who investigated the cacodyl radical, the geysers of Iceland, and the chemical action of light. Inventor of the Bunsen battery, the grease-spot photometer, ice and vapor calorimeters, the thermoregulator, the constant-level water-bath, and the filter pump. 

Bait Trees and Trap Out. In these treatments, behavioral chemicals (i.e. aggregation pheromones) are combined with a direct control method to produce beetle mortality. Baited trees have been evaluated using frontalure in a trap-tree application with the herbicide cacodylic acid (9, 10). This treatment was only partially effective. However, this technique does not affect the adult natural enemy population, but rather the FI generation of the natural enemy population which is killed. 

Figure 12. A comparison of the tern- g perature dependence of the thymidine H-3 proton chemical shift of poly(dA-dT) in 1M NaCl, lOmM cacodylate, O.lmM EDTA, H.O, pH 6.53 (9) and in /M (2H, C),NCl, lOmM phosphate, ImM EDTA, HiO, pH 7.5(0)...

Figure 15. The proton noise decoupled 145.7-MHz 31P NMR spectra of poly-(dA-dT) in IM (CH,),NCl. lOmM cacodylate, ImM EDTA, 2H.O, pH 7.95 at 67°C. The chemical shifts are upfield from standard trimethylphosphate.

Figure 18. The temperature dependence of (A) the thymidine CH.,-5 chemical shift and (B) the adenosine H-8 linewidth in poly(dA-dT) (O), the proflavine polv(dA-dT) complex, Nuc/D 24 (A) and Nuc/D = 8(9) in 1M NaCl, lOmM cacodylate, lOmM EDTA, sH.O, pH 7...

Figure 19. The temperature dependence of the nucleic acid (O) and proflavine (0) chemical shifts between 5.5 and 8.6 ppm for poly(dA-dT) and the Nuc/D = 24 and 8 proflavine poly(dA-dT) complexes in /M NaCl, lOmWl cacodylate, lOmM EDTA, 2 HO between 50° and 100°C. The poly(dA-dT) concentration was fixed at I2.6mM in phosphates and the proflavine concentration was varied to make the different Nuc/D ratio complexes.

Figure 36. The temperature dependence (40° to 100°C) of the sugar H-l chemical shifts of poly(dA-dT) (O) and the netropsin poly(dA-dT) complex, Nuc/D = 50 (9) in 01M cacodylate, 4.4mM EDTA, 2HlO solution...

Figure 39. The temperature dependence of the chemical shifts and linewidths of the base resonances of poIy(dA-dT) (O) and the Nuc/D = 50 netropsin poly-(dA-dT) complex ( J in 0.1 M cacodylate, 4.4mWl EDTA, 2HiO, pH 7.25...

Brantley L R, Cromwell T M and Mead J F, Detection of acetate ion by the reaction with arsenious oxide to form cacodyl oxide . Journal of Chemical Education, 1947,24,353. 

CACODYLIC ACID (75-60-5) Aqueous solution reacts with chemically active metals. Incompatible with sulfuric acid, caustics, ammonia, amines, isocyanates, alkylene oxides, epichlorohydrin. 

Bunsen was an avid experimentalist. He spent much of his time in the laboratory trying to discover the composition of chemical substances. His early research concerned the properties of arsenic and its compoimds. In particular, the chemical composition of a certain class of chemicals, called cacodyls, was unknown. His experiments showed that cacodyls were oxides of arsenic. But Bunsen s work with arsenic nearly cost him his life—he nearly killed himself through arsenic poisoning and lost the sight in one eye during his experiments with cacodyls. 

Alkarsin Cacodyl Diarsine, tetramethyl- EINECS 207-4404 Tetramethyldiarsenic Tetramethyidiarsine. Chemical intermediate. Platelets mp = -6° bp = 165° d = 1.447 slightly soluble in H2O, very soluble in EtOH, Et20,... 

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