Cacodylate,

Arsenic (but not antimony) forms a second hydride. This is extremely unstable, decomposing at very low temperatures. Replacement of the hydrogen atoms by methyl groups gives the more stable substance tetramethyldiarsane, cacodyl, (CH3)2As -AsfCHj), a truly foul-smelhng liquid. 

Diarsines are extremely reactive compounds. Tetramethyldiarsine (cacodyl) [471-35-2] and tetraethyldiarsine [612-08-8] CgH2QAs2, are... 

Sodium cacodylate (3H2O) [124-65-2] M 214.0, m 60°. Crystd from aqueous EtOH. 

SODIUM BISULFITE SODIUM BOROHYDRIDE SODIUM BROHATE SODIUM CACODYLATE SODIUM CHLORATE... 

HaO). Quinine salicylate, 2[B. CgH4(OH)(COOH)]. HaO, forms colourless needles, m.p. 187° (dec.), which slowly become pink in air. It is soluble in water (1 in 77 at 25°), alcohol (1 in 11 at 25°), or chloroform (1 in 37 at 25°). The foregoing are the most important quinine salts used in medicine, but many other salts have been used, e.g., the tannate, formate, valerate, ethylcarbonate, lactate, cacodylate, etc., as well as double salts such as quinine bismuth iodide. Descriptions of many of these salts will be found in the British Pharmaceutical Codex for 1934. 

Heat a very small quantity of potassium acetate with an equal bulk of arsenious oxide. The disagreeable and poisonous vapour of cacodyl oxide is evolved. 

If in an odoriferous body the atoms with which the possibility of free affinity exists be replaced by others where such possibility does not exist the odour is removed. Thus cacodyl would yield the odourless ethane methyl iodide would give methane ethyl hydro-selenide would yield ethane, and so on. 

Kakodyl, n. cacodyl, -saure, /. cacodylic acid, -wasserstoff, m. cacodyl hydride. 

F.16 Cacodyl, which has an intolerable garlicky odor and is used in the manufacture of cacodylic acid, a cotton herbicide, has a mass percentage composition of 22.88% C, 5.76% H, and 71.36% As and a molar mass of 209.96 g-mol. What is the molecular formula of cacodyl ... 

Tin oxide 0.24 M cacodylic horse heart cyto- 22 4.9-lOr CV 82Bow )... 

The rates of hydrolysis and binding to DNA of anti-DE-I, syn-DE-I, anti-DE-II, syn-DE-II, and anti-1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydrochrysene (anti-chrysene-DE) were studied in order to relate the chemical reactivity of these dihydrodiol epoxides to their biological activities. The half-lives of the dihydrodiol epoxides in cacodylate buffer at pH 7.0 and 37°C are summarized in Table III and their relative extents of binding to DNA in Table IV. It is clear that the rates of hydrolysis of the dihydrodiol epoxides do not correlate with their DNA binding properties. 

The experimentally observed pseudo-first order rate constant k is increased in the presence of DNA (18,19). This enhanced reactivity is a result of the formation of physical BaPDE-DNA complexes the dependence of k on DNA concentration coincides with the binding isotherm for the formation of site I physical intercalative complexes (20). Typically, over 90% of the BaPDE molecules are converted to tetraols, while only a minor fraction bind covalently to the DNA bases (18,21-23). The dependence of k on temperature (21,24), pH (21,23-25), salt concentration (16,20,21,25), and concentration of different buffers (23) has been investigated. In 5 mM sodium cacodylate buffer solutions the formation of tetraols and covalent adducts appear to be parallel pseudo-first order reactions characterized by the same rate constant k, but different ratios of products (21,24). Similar results are obtained with other buffers (23). The formation of carbonium ions by specific and general acid catalysis has been assumed to be the rate-determining step for both tetraol and covalent adduct formation (21,24). 

The experimental observations in cacodylate buffer solutions are consistent with a mechanism involving a kinetically common intermediate according to the following reaction scheme ... 

Calf Thymus 5 mM Sodium Cacodylate (7.1) 0.2% Tetra-hydrofuran 25 12,000... 

Figure 6. The variation of rate constants k (25 °C) with pH for the reaction of Fe(CN)64 with parsley plastocyanin PCu(II) [I = 0.10 M (NaCI)]. Key A, acetate and O, cacodylate. (Reproduced from Ref. 10. Copyright 1978, American...

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