Chemical Registry system

Description, Acquisition, Retrieval, and Correlation File. This is the only other pubhc substmcture search system, apart from CAS Online, that provides full access to the CAS Chemical Registry File. The DARC file, commercially available on-line from Telesystems-Questel, offered the first pubhc on-line implementation of substmctural searching of the CAS Chemical Registry System. The advantages and disadvantages of the CAS Online and DARC systems have been discussed (49). 

Weisgerber DW. Chemical Abstracts Service Chemical Registry System history, scope, and impacts. J Am Soc Inf Sci 1997 48 349-60. 

Freeland RG, Funk SA, O Korn LJ, Wilson GA. The CAS Chemical Registry System. II. Augmented connectivity molecular formula. / Chem Inf Comput Sci 1979 19 94-8. 

Dittmar, Stobaugh, and Watson [8] describe the connection table utilized in the CAS Chemical Registry System. Lefkowitz [9] describes a concise form of a connection table, called the Mechanical Chemical Code, which does not explicitly identify the bonds and has attributes of both a connection table and linear notation. 

Dittmar, P. G., R. E. Stobaugh, and C. E. Watson, "The Chemical Abstracts Service Chemical Registry System. I. 

CAS Registry Numbers are assigned in sequential order as substances are entered into the CAS Chemical Registry System database for the first time the numbers have no chemical significance. CAS Registry Numbers link the molecular structure diagram, systematic CA index name, synonyms, molecular formula,... 

CAS Registry Numbers are included in the printed Chemical Abstracts chemical substance and formula indexes and in the CAS databases. The full set of CAS Chemical Registry System database information—structures, names, formulas, and ring data—is available for search and display through STN International, SciFinder, and other CAS search services. CAS Registry information is also available in CAS databases offered by other online system vendors. 

During the eighth Collective Index period (1967 to 1971), the CAS Chemical Registry System was introduced (see Section 9.1), and chemical substances were further identified by their CAS Registry Numbers in the eighth and subsequent printed Collective Indexes and in Volume Indexes from Volume 71 (July to December 1969) onward. 

Appendix II Indexes to Chemical Abstracts Organisation and Use is a comprehensive account of the organisation, and relationships, of the CA Chemical Substance Index, CA General Subject Index, CA Formula Index, and CA Index of Ring Systems. This appendix also describes the CAS Chemical Registry System and the criteria applied in selecting CA index entries. 

Sci., 28, 175 (1988). Chemical Abstracts Service Chemical Registry System. 10. Registration of Substances from pre-1965 Indexes of Chemical Abstracts. 

Freeland, R.G., Funk, S.A., O Kom, L.J. and Wilson, G.A. (1979). The Chemical Abstract Service Chemical Registry System. II. Augmented Connectivity Molecular Formula. J.Chem.Inf. ComputSci., 19, 94-98. 

G. A. (1979) The chemical abstract service chemical registry system. 11. Augmented connectivity molecular formula. J. Chem. Inf. Comput. Sci., 19, 94-98. 

Conforming to these principles, Chemical Abstracts Service has devised a stereochemical notation which was first introduced into the Chemical Abstracts Service Chemical Registry. System and CA Indexes in 1972 (7) and was extended to higher coordination numbers in 1977 (8). 

Shortly after this activity was initiated, the National Library of Medicine (NLM) and the Food and Drug Administration (FDA) were given responsibility for providing more specific access to health-related information about drugs and chemicals. It was decided at that time to build a data base from the chemical registry system which would fit the specific requirements of NLM and FDA. A subsidiary project was established with Chemical Abstracts Service as part of the chemical registry contract, which is administered by the National Science Foundation. The data base was built from information available in the files of NLM and FDA and from approximately 40 standard reference sources on drugs and chemicals. 

The CAS Chemical Registry System is a computer-based system that uniquely identifies chemical substances on the basis of their molecular structures. Begun originally in 1965 to support indexing for Chemical Abstracts, the Registry System now serves not only as a support system for identifying substances within CAS operations but also as an international resource for chemical substance identification by scientists, industry, and regulatory bodies. 

The chemical structure files built by these software packages consist of connection tables, a form of structural representation used in the CAS Chemical Registry System, and in consequence by both CAS ONLINE and DARC, and incidentally in many other systems (including MACCS). Both CPSS and PSIDOM include modules for building chemical structure data bases on personal computers which, in the case of PSIDOM, are limited only by the capacity of the disk storage... 

Eastman Kodak has many laboratories worldwide, all with their own information departments, but the Information and Computer Technology Division in Rochester, and in particular the Application and Data Resources Unit, is responsible for the 555,000 compounds in the Chemical Registry System (under both MACCS and CAS Registry System software). There are also on file 17000 reactions under REACCS, 190,000 reports and 65,000 patents in a photographic patents index. The Chemical Information Centre holds 1,100,000 index cards, half of them in accession number order and half in molecular formula sequence. 

POSTER SESSION POTENTIAL ENHANCEMENTS TO THE CAS CHEMICAL REGISTRY SYSTEM... 

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