Cerebellum cell differentiation

In the treatment of diseases where the metaboUtes are not being deUvered to the system, synthetic metaboUtes or active analogues have been successfully adrninistered. Vitamin metaboUtes have been successfully used for treatment of milk fever ia catde, turkey leg weakness, plaque psoriasis, and osteoporosis and renal osteodystrophy ia humans. Many of these clinical studies are outlined ia References 6, 16, 40, 51, and 141. The vitamin D receptor complex is a member of the gene superfamily of transcriptional activators, and 1,25 dihydroxy vitamin D is thus supportive of selective cell differentiation. In addition to mineral homeostasis mediated ia the iatestiae, kidney, and bone, the metaboUte acts on the immune system, P-ceUs of the pancreas (iasulin secretion), cerebellum, and hypothalamus. 

Cerebellum granular cell migration TRal. Purkinje cell differentiation TRb1 + TRal... 

FIGURE 29-5 In the adult rodent brain, dividing cells in the subventricular zone adjacent to the lateral ventricle migrate in the rostral migratory stream (RMS) and differentiate into olfactory neurons in the olfactory bulb (OB). This is one site of neuronal turnover in the adult that appears to result from persistent generation of neurons from adult CNS stem cells. CIS, cerebellum NC, neocortex. 

Kopen, G. C., Prockop, D. J. and Phinney, D. G. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc. Natl Acad. Sci. U.S.A. 96 10711-10716,1999. 

Redies, C., U. Lendahl, and R. D. McKay. 1991. Differentiation and heterogeneity in T-antigen immortalized precursor cell lines from mouse cerebellum. JNeurosci Res 30(4) 601-15. 

Hansel C, Linden DJ, D Angelo E (2001) Beyond parallel fiber LTD the diversity of synaptic and non-synaptic plasticity in the cerebellum. Nat Neurosci 4 467-75 Hao J, Michalek C, Zhang W et al (2006) Regulation of cardiomyocyte signaling by RGS proteins differential selectivity towards G proteins and susceptibility to regulation. J Mol Cell Cardiol 41 51-61... 

In other brain regions such as the cerebellum, there are cells simultaneously undergoing proliferation, differentiation, migration, and apoptosis. Thus, the contribution of these basic cellular processes to organ development can vary temporally across organ regions and in relation to each other. 

Pisu MB, Guioli S, Conforti E, Bernocchi G (2003) Signal molecules and receptors in the differential development of cerebellum lobules. Acute effects of cisplatin on nitric oxide and glutamate systems in Purkinje cell population. Brain Res Dev Brain Res 145 229-240. 

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