Cell fate mapping

Photoactivated Gene Expression for Cell-fate Mapping and Cell Manipulation ... 

Minden, J., Namba, R., MergUano, J., and Cambridge, S., Photoactivated gene expression for cell fate mapping and cell manipulation, Sci. STKE 2000, 62, LI, 2000. 

Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K (2006) Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev 20 1123-1136... 

Tavian M, Robin C, Coulombel L and Peault B (2001). The human embryo, but not its yolk sac, generates lympho-myeloid stem cells, mapping multipotent hematopoietic cell fate in intraembryonic mesoderm. Immunity 15 487-495. 

W. Janning, Gynandromorph fate maps in Drosophila. In Genetic Mosaics and Cell Differentiation, W. J. Gehring, ed., Springer-Verlag, Berlin, 1978, pp. 1-28. 

In order to begin to address these questions, it was necessary to understand which cells give rise to the different limb parts. Fate maps of the limb bud were con-... 

Fate maps only reveal contributions of cells in different regions but do not show when decisions to form a particular structure have been taken. Once cells have taken this decision, which seals their fate irreversibly, they are said to be determined and the traditional test for determination is transplantation. If cells are determined, they will develop autonomously when transplanted into a different region of an embryo if they are not, they will change fate and develop according to their new site (Slack, 1991). 

Klapper, R., Holz, A., and fanning, W. (1998). Fate map and cell lineage relationships of thoracic and abdominal mesodermal anlagen in Drosophila melanogaster. Mech. Dev. 77 77-87. 

Serbedzija GN, Bronner-Fraser M, Fraser SE (1989) A vital dye analysis of timing and pathways of avian neural crest cell migration. Development 106 809-816. Kinder SJ, Tan S-S, Tam PPL (2000). Cell grafting and fate mapping of the early-somite-stage mouse embryo. In Methods in molecular biology, vol.l, pp. 425 37, Developmental Biology Protocols, vol. 135. 

Smith, J. L., Gesteland, K. M., and Schoenwolf, G. C. (1994) Prospective fate map of the mouse primitive streak at 7.5 days of gestation. Dev. Dyn. 201, 279-289. Gossler, A., Joyner, A. L., Rossant, J., and Skames, W. C. (1989) Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. 

Labeling single cells in ovo and then studying their fate during subsequent development can be a powerful tool in the investigation of how embryos develop. It can be used to construct fate maps at the single-cell level, analyze... 

After the fourth (meridional) and fifth (equatorial) cleavages, the embryo comprises 32 cells, arranged in four tiers of eight cells (stage 6 of Nieuwkoop and Faber). The fates of these cells have been determined by microinjection of cell lineage markers (8,9), and the fate map of Dale and Slack is shown in Fig. 2. Notice that individual cells at this stage are far from restricted to a single fate, and that there may be considerable variation from embryo to embryo. 

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