Cefadroxil

The court found that Novopharm had established that its product would not contain Form 2, and that if the product did contain Form 2, then it would be present as an independent component or impurity, not as the basis for some improvement or equivalent. The court thus allowed Novopharm to market mixtures of Forms 1 and 2. 

Cefadroxil (also sometimes spelled cephadroxil), an antibiotic originally developed by Bristol-Myers (BM) and marketed under the trade names Ultracef and Duricef, had combined sales in the US of 100 million in 1988. A crystalline monohydrate (apparently discovered serendipitously), claimed in U.S. Patent No. 4,504,657 (the 657 patent) issued in March 1985, is described in the patent in terms of its X-ray diffraction pattern (Fig. 10.2). The improvement of this substance over the earlier known material included greater stability and high bulk density, properties which enabled the production of smaller pills. 

Prosecution of this patent was in fact quite lengthy, the original application dating from August 1979, and involved questions of similarities and differences in crystalline modifications. (See Kalipharma v. Bristol-Myers 1989 for details of the history of the prosecution of the patent application.) The prior art included a 1973 patent (U.S. 

Daniel Bouiard, FranconviHe Abraham Weber Jacques Sterner, both of Paris, all of France 

Aitorney. Agent, or Firm—Robert E. Carnahan David 

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Amino-3-methyl-3carboxylic acid Cefadroxil... 

Ethyl chlorocarbonate Amo xapine Amoxicillin Ampicillin Cefadroxil Ethyl chloroformate Azidocillin Fominoben HCI Hydroxyphenamate Lo xapine... 

Cephalexin, cephradine, cefaclor, cefadroxil, cefuroxime, cefixime, cefzil, cefpodoxime... 

Kurosaki, Y., Nishimura, H., Terao, K., Nakayama, T., Kimura, T., Existence of a specialised absorption mechanism for cefadroxil, an amino-cephalosprorin antibiotic, in the human oral cavity, Int. J. Pharm. 1992, 82, 165-169. 

First-generation cephalosporins—IV cefazolin po cephalexin, cephradine, or cefadroxil. cSome penicillin-allergic patients may react to cephalosporins. 

Didoxacillin 25-50 mg/kg in four divided doses Cephalexin 25-50 mg/kg in two to four divided doses Cefadroxil 30 mg/kg in two divided doses Clindamycin 10-30 mg/kg/day in three to four divided doses0 Mupirocin ointment every 8 hours0... 

Penicillins Ampicillin Amoxicillin-davulanic add Cephalosporins Cephalexin Cefaclor Cefadroxil Cefuroxime Cefixime Cefzil... 

The pediatric dose of cefadroxil is 30 mg/kg/day. A child is receiving a daily dose of 2 tsp of a pediatric cefadroxil suspension based on the body weight. If the child s weight is 18.3 lb, how many milligrams of the drug is the child receiving in each dose ... 

A. Tsuji, E. Nakashima, Y. Deguchi, K. Nishide, T. Shimizu, S. Horiuchi, K. Ishikawa, T. Yamana, Degradation Kinetics and Mechanism of Aminocephalosporins in Aqueous Solution Cefadroxil , J. Pharm. Sci. 1981, 70, 1120-1128. 

Sancho-Chust, V., Bengochea, M., Fabra-Campos, S., Casabo, V.G., Martinez-Camara, M.J., and Martin-Villodre, A., Experimental studies on the influence of surfactants on intestinal absorption of drugs. Cefadroxil as model drug and sodium lauryl sulfate as model surfactant studies in rat duodenum, Arzneim.-Forsch./Drug Res., 45, 1013, 1995. 

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