Clindamycin dosing

Although tetracycline, doxycycline, and minocycline are the most commonly prescribed oral antibiotics for acne, erythromycin and clindamycin are appropriate second-line agents for use when patients cannot tolerate or have developed resistance to tetracycline or its derivatives.3 See Table 62-3 for antibiotic dosing guidelines. 

Clindamycin Capsules 75, 1 50, 300 mg 1 50-300 mg daily Maintenance dose 1 50 mg daily Diarrhea, pseudomembranous colitis... 

Clindamycin 20-30 mg/kg per day in 3-4 doses (adult 300 mg four times daily or 450 mg three times daily) Nausea, diarrhea, C. difficile colitis, anorexia S Oral liquid has very poor taste only for pneumococcal infection... 

Clindamycin 150-450 mg 3-4 times daily 20-40 mg/kg per day in 3—4 doses No gram-negative coverage use in combination... 

Clindamycin 1 50 mg 4 times daily 20-30 mg/kg per day in 3 doses 1 0 days Useful for recurrent infections... 

If GAS is identified as the sole causative organism from deep tissue culture, antimicrobial therapy can be narrowed to high-dose IV penicillin G plus clindamycin. Antibiotic therapy should be continued until further operative debridements are unnecessary, the patient displays substantial clinical improvement, and fevers have abated for at least 48 to 72 hours.3... 

Clindamycin 900 mg IV every 8 hours and gentamicin, loading dose IV or IM (2 mg/kg) followed by maintenance dose (1.5 mg/kg) every 8 hours (a single daily dose may be used)... 

Primaquine is also gametocytocidal and a single dose of 30-45 mg has been suggested to prevent transmission of falciparum malaria particularly in areas where there is a potential for reintroduction of malaria. Primaquine is also used in the treatment of Pneumocystis carinii pneumonia in AIDS patients in combinations with clindamycin [3]. 

Clindamycin 600 mg orally divided in two to four doses 20 mg/kg/day in three divided doses (maximum 1.8 g/day)... 

High-dose amoxicillin or clindamycin. Second choice respiratory fluoroquinolone. 

Clindamycin 150-450 mg every 6 hours 30-40 mg/kg/day divided in three doses... 

Didoxadllin 25-50 mg/kg in four divided doses Cephalexin 25-50 mg/kg in four divided doses Clindamycin 10-30 mg/kg/day in three to four divided doses0 Penicillin VK 25,000-90,000 units/kg in four divided doses Clindamycin 10-30 mg/kg in three to four doses0 Erythromycin 30-50 mg/kg in four divided doses0... 

Initial IV therapy, followed by penicillin VK 25,000-90,000 units/kg in four divided doses Clindamycin 10-30 mg/kg/day in three to four divided doses0... 

Moderat severe infection Aminoglycoside + clindamycin 0.6-0.9 g IV every 8 hours or metronidazole Aminoglycosidee plus clindamycin 15 mg/kg/day IV in three divided doses or metronidazole 50-50... 

Maxillofacial surgery Staphylococcus aureus, streptococci oral anaerobes Cefazolin 2 g or clindamycin 600 mg Repeat intraoperative dose for operations longer than 4 hours IA... 

Head and neck cancer resection Cardiothoracic surgery 5. aureus, streptococci oral anaerobes Clindamycin 600 mg at induction and every 8 hours x 2 more doses Add gentamicin for clean-contaminated procedures IA... 

Clindamycin shows in vitro activity against Pro-pionibacterium acnes and topically applied clindamycin is effective for the treatment of acne. Approximately 10% of an applied dose is absorbed. In spite of this absorption pseudo-membranous colitis with bloody diarrhea is seldom seen. 

Obstetric infections can be treated with penicillin-beta-lactamase inhibitors such as amoxicillin-clavulanic acid, with extended spectrum penicillins (with or without beta-lacamase inhibitors if justified by local resistance surveillance data), with a first or second generation cephalosporin combined with metronidazole. In severe cases of streptococcal infection high doses of penicillin in combination with clindamycin is the treatment of choice. In amnionitis, maternal morbidity resolves with delivery. In endometritis, antibiotics should be stopped after the... 

In fasciitis or necrotizing infections caused by beta-hemolytic streptococci of group A, parenteral high-dose penicillin combined with clindamycin is the treatment of choice. For the treatment of abscesses, antibiotics which are able to kill large quantities of resting bacteria, such as clindamycin and the quinolones, are preferred. 

Space doses evenly around the clock and continue taking clindamycin for the full course of treatment... 

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