Cefadroxil monohydrate

Figure 6.30 The mass chromatograms (EIC profiles) of selected degradants at the m/z values corresponding to their [M+H]+ ions in a base-degraded cefadroxil monohydrate sample. (Reprinted with permission from Rourick et al., 1996. Copyright 1996 Elsevier.)...

Baxan Baxan Kapsein Bidocef Bidocel BL-S 578 Cefa-Drops Cefadroxil Cefadroxil monohydrate Cefamox Ceforal Cefos Granulat Cephos Duracef Duricef Kefroxil Kefroxil Kapsein MJF 11567-3 Moxacef Kapsein, Omnidrox Kapsein, Oracefal Sedral Ultracef. Antibacterial. A semisynthetic cephalosporin antibiotic intended for oral admin-isiration. It is a white to yellowish-white crystalline powder. It is soluble in water and it is acid-stable. Powder, mp = 197° (dec). Bristol-Myers Squibb Pharm. R D Mead Johnson Labs. 

The following cephalosporins were chromatographed cephalosporin C dihydrate (1), cefadroxil monohydrate (2), cefatrizine propylene-glycolate (3), cefaloglycin dihydrate (4), cefaclor monohydrate (5), cefalexin monohydrate (6), cefradine anhydrate (7), cefamandole (8), cefalotin (9), cefoxitin (10), cefaloridine 6-form (11), cefapirin... 

Baxan (Cefadroxil monohydrate) Bristol-Myers Pharmaceuticals, UK Summary of product characteristics, July 2005. 

An analysis of all crystal structures available in the Cambridge Structural Database for hydrates of /8-lactams reveals that the water molecules in the crystal structures are not in sufficient proximity (within the sum of van der Waals distance) to the reactive center on the /8-lactam core to bring about reaction. For cases where water molecules are in close proximity to the reactive centre, further rationalization can be made in terms of the relative orientation of reactants and the steric hindrance of the initial approach of the water, or the low degree of conformational flexibility in the crystal. This type of calculation on cefadroxil monohydrate (reaction scheme shown in Figure 3.6) which contains a water molecule within van der Waals distance of the reactive /8-lactam carbonyl group, has shown that several atoms would lie outside of the molecular surface formed by the rest of the crystal, indicating steric clashes. 

Reactive in solution Permanganate Tetrahydropalmatine (tablets) reserpine (Ph) rescinnamine (Ph) yohimbine (Ph) medazepam (Ph) cefadroxil monohydrate (Ph and BF) salicylamide (Ph and urine) perphenazine (synthetic formulations) dipyridamole (tablets and injections) etilefrine hydrochloride (Ph and BF) isoxsuprine hydrochloride (Ph and BF) prenalterol hydrochloride (Ph and BF) amidopyrine (Ph) pipemidic acid (Ph) ethamsylate (Ph) folic acid (Ph) sulphonamides (Ph) chloramphenicol (Ph)... 

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