Cartilage matrix protein

W. A. Horton J. T. Hecht, Chondrodysplasias Disorders ot Cartilage Matrix Proteins. In Connective Tissue and Its Heritable Disorders, P. M. Royce, B. Steinmann, Eds. Wiley-Liss New York, 2002 pp 909-937. 

Beck, K., Gambee, J. E., Kamawal, A., and Bachinger, H. P. (1997). A single amino acid can switch the oligomerization state of the a-helical coiled-coil domain of cartilage matrix protein. EMBOJ. 16, 3767-3777. 

MacLeod J N, Fubini S L, Gu D N et al 1998 Effect of synovitis and corticosteroids on transcription of cartilage matrix proteins. American Journal of Veterinary Research 59 1021-1026... 

A previously unrecognized cartilage-matrix protein associated with proteoglycans was identified when the proteoglycans of bovine cartilage were isolated in the absence of dissociative solvents.The protein (mol. wt. 2 X 10 ) which co-fractionated with proteoglycan in all systems contains sub-units (mol. wt. 6x10" ). 

Proteoglycans may be soluble and located in the extracellular matrix, as is the case for serglycin, versican, and the cartilage matrix proteoglycan, or they may be integral transmembrane proteins, such as syndecan. Both types of proteoglycan... 

TGF-Ps are pleiotrophic cytokines. They are capable of inhibiting the cell cycle and, hence, cell growth of several cell types, most notably epithelial and haematopoietic cells. These factors, however, stimulate the growth of other cell types, most notably cells that give rise to connective tissue, cartilage and bone. They induce the synthesis of extracellular matrix proteins and modulate the expression of matrix proteases. They also serve as a powerful chemoattractant for monocytes... 

Kajava, A. V. (1996). Modeling of a five-stranded coiled coil structure for the assembly domain of the cartilage oligomeric matrix protein. Proteins 24, 218-226. 

Wong M, Siegrist M, Cao X. Cyclic compression of articular cartilage explants is associated with progressive consolidation and altered expression pattern extracellular matrix proteins. Matrix Biol. 1999 18 391-399. 

Schematic representation of the molecular organization of structural elements in cartilage matrix. Collagen fibrils provide tensile forces, and proteoglycans, because of their large solvent domains, accommodate reversible compressible forces. LP = link protein HA = hyaluronate KS = keratan sulfate CS = chondroitin sulfate PC = core protein. [Reproduced with permission from L. C. Junqueira, J. Carneiro, and J. A. Long, Basic Histology, 5th ed. Appleton Lange, Norwalk, CT, 1986. 1986 Appleton-Century-Crofts.]...

Connective tissue, such as tendon and cartilage, differs from other solid tissues In that most of Its volume Is made up of extracellular matrix rather than cells. This matrix Is packed with Insoluble protein fibers and contains proteoglycans, various multladhesive proteins, and hyaluronan, a very large, nonsulfated GAG. The most abundant fibrous protein In connective tissue Is collagen. Rubberlike elastin fibers, which can be stretched and relaxed, also are present In deformable sites (e.g., skin, tendons, heart). As discussed later, the fibronectins, a family of multladhesive matrix proteins, form their own distinct fibrils In the matrix of some connective tissues. Although several types of cells are found In connective tissues, the various ECM components are produced largely by cells called fibroblasts. 

Aggrecan turnover CS-846, CTX-MMP, C1-2C Cartilage oligomeric matrix protein (COMP)... 

Nguyen Q, Murphy G, Hughes CE, Mort JS, Roughley PJ. Matrix metallo-proteinases cleave at two distinct sites on human cartilage link protein. Biochem J 1993 295 595-598. 

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