Carriers polysaccharides

Kunz H., Hofmeister A., Glaser B. Stereoselective Syntheses Using Carbohydrates as Carriers of Chiral Information in Polysaccharides 1998 539, Ed. Severian D., Pb. Dekker N.Y. 

Release profiles of these immunogens ean be improved through their formulation with adjuvants (Chapters 14, 15), and the immunogenieity of certain purified baeterial eomponents such as polysaccharides ean be improved by their conjugation to a carrier. 

Three typhoid vaccines are available currently for use in the United States (1) an oral live-attenuated vaccine (Vivotif Berna-TM vaccine, Swiss Serum and Vaccine Institute), (2) a parenteral heat-phenol-inactivated vaccine (Typhoid Vaccine, Wyeth-Ayerst), and (3) a parenteral capsular polysaccharide vaccine (Typhim Vi, Pasteur Merieux). Immunization is recommended only for travelers going to endemic areas such as Latin America, Asia, and Africa household contacts of a chronic carrier and laboratory personnel who frequently work with S. typhi.13... 

Probably the most promising polymeric drug carrier system involves polysaccharide molecules. These are natural polymers and are often biodegradable to products that are useful to the host or easily eliminated by the host. Dextrans have been the most extensively used polysaccharide for macromolecular prodrug preparations (79). These materials are biocompatible and the in vivo fate is directly related to their molecular weight. Moreover these macromolecules can be easily targetted to the hepatocytes with D-mannose or L-fucose (20). 

E. Schacht, Polysaccharide macromolecules as drug carriers, in Polymers, in Controlled Drug Delivery (L. Ilium and S. S. Davis, eds.), Wright, Bristol, 1987, p. 131. 

With respect to macromolecular drug-carrier approaches, the linear polysaccharide poly a-l,6-maltotriose (pullulan -OH) was combined with l-aminopropan-2-ol via the succinate ester in the following way [1613... 

Purified capsular polysaccharide of H. influenzae type b (usually linked to a protein carrier, forming a conjugated vaccine)... 

Haemophilus influenzae type b (Hib) vaccines currently in use are conjugate products, consisting of either a polysaccharide or oligosaccharide of polyribosylribitol phosphate (PRP) covalently linked to a protein carrier. 

Antigen is a substance that stimulates an immune response, especially the production of antibodies. Antigens are usually proteins or polysaccharides, but can be any type of molecule, including small molecules (haptens) coupled to a carrier-protein. 

A special group of carrier-linked prodrugs are the site-specific chemical delivery systems [23], Macromolecular prodrugs are synthetic conjugates of drugs covalently bound (either directly or via a spacer) to proteins, polypeptides, polysaccharides, and other biodegradable polymers [24],... 

The most widely used CSPs can be classified into three groups (i) CSPs with low-molecular-weight selectors, such as Pirkle-type CSPs, ionic- and ligand-exchange CSPs, (ii) CSPs with macrocyclic selectors such as CDs, crown-ethers and macrocyclic antibiotics, and (iii) CSPs with macromolecular selectors such as polysaccharides, synthetic polymers, molecular imprinted polymers and proteins. It can be observed that several of the chiral selectors applied in CE are used in LC. They are then bonded or coated to an inert carrier to form the CSP. 

We have used of water-soluble polymers, such as polysaccharides, as carriers of antitumor agents to reduce their side effects [3]. In this study,... 

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