Macromolecular Drug Carriers

Another very important site for drug delivery is the central nervous system (CNS). The blood-brain barrier presents a formidable barrier to the effective delivery of most agents to the brain. Interesting work is now advancing in such areas as direct convective delivery of macromolecules (and presumably in the future macromolecular drug carriers) to the spinal cord [238] and even to peripheral nerves [239]. For the interested reader, the delivery of therapeutic molecules into the CNS has also been recently comprehensively reviewed... 

With respect to macromolecular drug-carrier approaches, the linear polysaccharide poly a-l,6-maltotriose (pullulan -OH) was combined with l-aminopropan-2-ol via the succinate ester in the following way [1613... 

Takakura, Y., and Hashida, M. (1995), Macromolecular drug carrier systems in cancer chemotherapy Macromolecular prodrugs, Crit. Rev. OncoL/Hematol., 18, 207-231. 

Seymour, L.W. Miyamoto, Y. Meada, H. Brereton, M. Strohahn, J. Ulbrich, K. Duncan, R. Influence of molecular weight on passive tumor accumulation of a soluble macromolecular drug carrier. European Journal of Cancer... 

Kissel, M., Peschke, P, Subr, V., Ulbrich, K., Strunz, A. M., Kuehnlein, R., Debus, J., Friedrich, E. Detection and cellular localisation of the synthetic soluble macromolecular drug carrier pHPMA. Eur. J. Nucl. Med. Mol. Imaging 2002, 29(8), 1055-1062. 

The discussion of active ester synthesis in this review focuses on polymers and copolymers of phenyl acrylates and iV-acryloyloxy tkrivatives as synthetic intermediates . Another interesting application of activated (meth)acrylates is the formation of photocurable oligomers [81]. Polymers and copolymers of activated (meth)acrylates have also been studied as models of macromolecular drug carriers [37, 42], In addition, the chemistry of activated esters is equally... 

Duncan, R. (1987) Selective endocytosis of macromolecular drug carriers. In Robinson, J.R. and Lee, V.H. (eds). Controlled Drug Delivery Fundamentals and Applications. 2nd edn, pp. 581-607. Marcel Dekker, New York. 

Seymour LW, Miyamoto Y, Brereton M, Subr V, Strohalm J, Duncan R. Influence of molecular size on passive tumour-accumulation of soluble macromolecular drug carriers. Eur J Cancer 1995 5 766-770. 

Washington, D.C., 20th-24th Aug.2000, p. 1726-7 TRANSPORT OF MACROMOLECULAR DRUG CARRIERS ACROSS MICROVASCULAR BEDS... 

Kissel, M., P. Peschke, V. Subr, K. Ulbrich, J. Schuhmacher, J. Debus and E. Friedrich, 2001, Synthetic macromolecular drug carriers biodistribution ofpoly[(N-2-hydroxypropyljmethacrylamide] copolymers and their accumulation in solid rat tumors. PDA JPharm Sci Technol 55 191-201. 

Dreher MR, Liu W, Michelich CR, Dewhirst MW, Yuan F, Chilkoti A. Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. / Natl Cancer Inst 2006 98 335-344. 

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