Polysaccharide-Based Non-viral Carriers

To overcome this, chitosan nanoparticles with various chemical compositions, degrees of polymerization and branched chain modification have 

Hyaluronan (also called hyaluronic acid or hyaluronate or HA) is an anionic water-soluble polysaccharide that is distributed widely throughout connective, epithelial and neural tissues. It is one of the main components of the extracellular matrix and widely contributes to cell proliferation and migration. HA is approved for injections by FDA for its 

Other polysaccharide derivatives such as hydro) ethyl, anionic sugar polymer gellan gum and chondroitin sulfate can all be grafted with 

PEI to improve the transfection efficiency and decrease the cytotoxicity. For example, a cationic hexadecyl/DNA nanoparticle was transfected successfully into cells, thus increasing the pDNA expression. It was also reported that, after introducing PEI into GG, it can significantly reduce the cytotoxicity with the same efficiency in vitro and in vivo compared with PEI or Lipofectamine. 

3 Other Cationic Polymer-Based Non-viral Carriers 

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