Polypeptides and polysaccharides as carriers

Carbohydrates are the natural compounds possessing the most asymmetric centers in molecules that make them prospective auxiliaries for the preparation of chiral adsorbents and chiral catalysts. 

Optically pure (+)-lactose was used for the ehromatographie resolution of racemic /7ora-phenylenecamphor. 

Chiral adsorbents, like lactose, starch, and paper eellulose, gained applications in analytical and practical uses. Optically pure lactose was used by Henderson and Rule for the resolution of racemic / ara-phenylene-bis-iminocamphor in chromatographic columns. The (+)-enantiomer was more strongly adsorbed than the (-)-enantiomer. 

Hydrogenation of ethyl acetoacetate was investigated in the presence of Ru complex [Ru(CO)3CL2]2 bounded with optically active copolymer of Na-maleate-(S)-(2-methylbutyl) vinyl ether and with poly-sodium glutamate. Only the latter catalyst revealed a low ee of 3% at 100°C and 80 bar V 

Beamer R.L., Belding R.H. and Fickling C.S. (1969) Stereospecific hydrogenation. Comm. IV. Pd-on-poly-(S -valine) and Pd-on-poly-i S-leu-cm ),J. Pharm. Sci. 58, 1419-1421. 

---