Medullary thyroid carcinoma

Holm R, Farrants GW, Nesland JM, et al. Ultrastructural and electron immunohistochemical features of medullary thyroid carcinoma. Virchows Arch. A Pathol. Anat. Histopathol. 1989 414 375-384. [Pg.283]

Figure 4. Gamma camera image of a patient with medullary thyroid carcinoma showing selective uptake of Re-186-DMSA in a tumor at the base of the neck (taken 24 h after injection).

Creutzfeldt-Jakob disease (CJD) Alzheimer s disease (AD) Hemodialysis-related amyloidosis Primary systemic amyloidosis Secondary systemic amyloidosis Familial amyloid polyneuropathy I Familial amyloid polyneuropathy III Cerebral amyloid angiopathy Finnish hereditary systemic amyloidosis Type II diabetes Injection-localized amyloidosis Medullary thyroid carcinoma Atrial amyloidosis... [Pg.199]

Several inherited cancer syndromes are also known to result from mutations in proto-oncogenes. An example is given by the RET proto-oncogene. Depending on the type of mutation and on which part of the gene is affected, RET mutations can lead to multiple endocrine neoplasia 2A or 2B or familial medullary thyroid carcinoma. These familial cancers are inherited in autosomal dominant fashion. A second example is the CDK4 proto-oncogene, which when mutated can cause familial melanoma. [Pg.340]

Gastrointestinal, pancreas, biliary, lung, transitional cell, sweat glands, mucosal squamous cell, mucinous carcinomas of female GU tract, medullary carcinoma of thyroid Breast, squamous cell, endometrioid, Brenner tumor Renal cell, hepatocellular, prostate, follicular thyroid, adrenal cortical, serous carcinomas of female GU tract, embryonal, yolk sac, mesothelioma... [Pg.426]

CCK receptors SCLC, pancreatic cancers, neuroblastomas, meningiomas, medullary thyroid carcinomas... [Pg.267]

In 11 patients with medullary thyroid carcinoma Hoegerle et al. compared [i F]-DOPA-PET with [ F]FDG-PET, SRS and conventional imaging [220]. A total of 27 tumors were studied and the corresponding sensitivities were 63% for p F]DOPA-PET, 44% for p8F]-FDG-PET, 52% for SRS and 81% for conventional imaging. With respect to lymph node staging, the best results were obtained with [ F]DOPA-PET. [Pg.181]

S. Hoegerle, C. Altehoefer, N. Ghanem, I. Brink, E. Moser, E. Nitzsche, F-DOPA positron emission tomography for tumor detection in patients with medullary thyroid carcinoma and elevated calcitonin levels, Eur. J. Nucl. Med. 28(1) (2001) 64-71. [Pg.196]

Medullary thyroid carcinoma Mutation RET RET, VEGFR2, VEGFR3, EGFR, etc. (tyrosine-kinase activity) Vandetanib, Cabozantinib... [Pg.51]

Human CGRP (hCGRP) is a 37-residue polypeptide isolated by Morris et al. (127) from human medullary thyroid carcinoma. It acts as a vasodilator and stimulates the formation of cAMP. [Pg.2202]

EXCESS is found in medullary thyroid carcinoma and may result in a mild hypocalcemia. [Pg.66]

Positive Gastrointestinal, pancreas, biliary, lung, transitional cell, sweat glands, mucosal squamous cell, mucinous carcinomas of female GU tract, medullary carcinoma of thyroid... [Pg.417]

Vitale G, Ciccarelli A, Caraglia M, Galderisi M, Rossi R, Del Prete S, Abbruzzese A, Lupoli G. Comparison of two provocative tests for calcitonin in medullary thyroid carcinoma omeprazole vs pentagastrin. Clin Chem 2002 48(9) 1505-10. [Pg.2773]

Takami, H. et al. (1992) Calcitonin gene-related peptide as a tumour marker for medullary thyroid carcinoma. Int. Surg.. 77.181-185. [Pg.274]

Multiple endocrine neoplasia type II with medullary thyroid carcinoma and pheochroniocytoma Malignancy... [Pg.1895]

Calcitonin is secreted by the parafollicular or C cells, which arise from the neural crest and are distributed throughout the thyroid gland. These cells are included in the APUD (cmine precursor uptake and decarboxylation) family, which explains the association of medullary thyroid carcinoma (a tumor of the C cells) and other tumors of the APUD family in multiple endocrine neoplasia type 2A and -2B (MEN-2A and MEN-2B). Release of calcitonin is stimulated by calcium, and it has been used pharmacologically as an inhibitor of bone resorption. [Pg.1926]

Multiple forms of circulating calcitonin have been reported in normal individuals and patients with medullary thyroid carcinoma (MTC) or nonthyroidal malignancies. Much of the immunoreactive calcitonin generally migrates as larger forms rather than with monomeric calcitonin. A... [Pg.1926]

C-cell hyperplasia Medullary thyroid carcinoma Nonthyroidal cancers... [Pg.1927]

Barbot N, Calmettes C, Schuffenecker I, Saint-Andre JP. Pentagastrin stimulation test and early diagnosis of medullary thyroid carcinoma using an immunora-diometric assay for calcitonin comparison with genetic screening in hereditary medullary thyroid carcinoma. J Clin Endocrinol Metab 1994 78 114-20. [Pg.1944]

Body JJ, Heath H III. Nonspecific increases in plasma immunoreactive calcitonin in healthy individuals discrimination from medullary thyroid carcinoma by a new extraction technique. Chn Chem 1984 30 511-14. [Pg.1945]

Gagel RE. Multiple endocrine neoplasia type II and familial medullary thyroid carcinoma impact of genetic screening on management. Cancer Treat Res 1997 89 421-41. [Pg.1950]

Gharib H, Kao PC, Heath H III. Determination of silica-purified plasma calcitonin for the detection and management of medullary thyroid carcinoma comparison of two provocative tests. Mayo Clin Proc 1987 62 373-8. [Pg.1951]

Goltzman D, Tischler AS. Characterization of the unmunochemical forms of calcitonin released by a medullary thyroid carcinoma in tissue culture. J Clin Invest 1978 61 449-58. [Pg.1951]

Modigliani E, Franc B, Niccoli-sire P. Diagnosis and treatment of medullary thyroid carcinoma. Bailliere s Best Pract Res CHn Endocrinol Metab 2000 14 631-49. [Pg.1957]

Pacini F, FontaneUi M, Fugazzola L, Elisei R, Ehsei R, Romei C, Di Coscio G, et al. Routine measurement of serum calcitonin in nodular thyroid diseases allows the preoperative diagnosis of unsuspected sporadic medullary thyroid carcinoma. J Clin Endocrinol Metab 1994 78 826-9. [Pg.1958]

Perdrisot R, Bigorgne JC, Guhloteau D, Jallet P. Monoclonal immunoradiometric assay of calcitonin improves investigation of famhial medullary thyroid carcinoma, Clin Chem 1990 36 381-3. [Pg.1958]

Rieu M, Lame MC, Richard A, Lissak B, Lissak B, Sambort B, et al. Prevalence of sporadic medullary thyroid carcinoma the importance of routine measurement of serum calcitonin in the diagnosis and evaluation of thyroid nodules. Clin Endocrinol (Oxf) 1995 42 453-60. [Pg.1959]

Rude RK, Matsumoto S, Singer FR. Heterogeneity of immunoreactive calcitonin in extracts of medullary thyroid carcinoma. Miner Electrolyte Metab 1982 7 292-7. [Pg.1960]

Rude RK, Singer FR. Comparison of serum calcitonin levels after a 1-minute calcium injection and after pentagastrin mjection in the diagnosis of medullary thyroid carcinoma. J Clin Endocrinol Metab 1977 44 980-3. [Pg.1960]

Zink A, Blind E> Raue F. Determination of serum calcitonin by immunometric two-site assays in normal subjects and patients with medullary thyroid carcinoma. Eur J Clin Chem Clin Biochem 1992 30 831-5. [Pg.1965]

Tg is primarily used as a tumor marker in patients carrying a diagnosis of differentiated thyroid carcinoma (DTC). Although serum Tg is elevated in patients with thyroid cancer, including thyroid follicular and papillary carcinoma, elevations are also are seen in nonneoplastic conditions such as thyroid adenoma, subacute thyroiditis, Hashimoto s thyroiditis, and Graves disease. Serum Tg concentrations are not increased in patients with medullary thyroid carcinoma. [Pg.2084]

Iq21-q22 66.10 NTRK1 Neurotrophic tyrosine kinase, receptor, type 1 191315 Insensitivity to pain with anhidrosis, medullary thyroid carcinoma, self-mutilating behavior, mental retardation... [Pg.331]

BODEI, L., et al.. Receptor radionuclide therapy with Y-DOTATOC in patients with medullary thyroid carcinomas. Cancer Biother. Radiopharm. 19 (2004) 65-71. [Pg.306]

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