Cancer Medullary thyroid carcinoma

Somatostatin 14,28 Neuroendocrine, small cell lung cancer, medullary thyroid carcinoma, astrocytoma... [Pg.2193]

Several inherited cancer syndromes are also known to result from mutations in proto-oncogenes. An example is given by the RET proto-oncogene. Depending on the type of mutation and on which part of the gene is affected, RET mutations can lead to multiple endocrine neoplasia 2A or 2B or familial medullary thyroid carcinoma. These familial cancers are inherited in autosomal dominant fashion. A second example is the CDK4 proto-oncogene, which when mutated can cause familial melanoma. [Pg.340]

CCK receptors SCLC, pancreatic cancers, neuroblastomas, meningiomas, medullary thyroid carcinomas... [Pg.267]

C-cell hyperplasia Medullary thyroid carcinoma Nonthyroidal cancers... [Pg.1927]

Gagel RE. Multiple endocrine neoplasia type II and familial medullary thyroid carcinoma impact of genetic screening on management. Cancer Treat Res 1997 89 421-41. [Pg.1950]

Tg is primarily used as a tumor marker in patients carrying a diagnosis of differentiated thyroid carcinoma (DTC). Although serum Tg is elevated in patients with thyroid cancer, including thyroid follicular and papillary carcinoma, elevations are also are seen in nonneoplastic conditions such as thyroid adenoma, subacute thyroiditis, Hashimoto s thyroiditis, and Graves disease. Serum Tg concentrations are not increased in patients with medullary thyroid carcinoma. [Pg.2084]

BODEI, L., et al.. Receptor radionuclide therapy with Y-DOTATOC in patients with medullary thyroid carcinomas. Cancer Biother. Radiopharm. 19 (2004) 65-71. [Pg.306]

Mendelsohn G, Wills Jt SA, Baylin SB. Relationship of tissue catcinoembtyonic antigen and calcitonin to tumot virulence in medullary thyroid carcinoma An immunohistochemical study in eatly, localized and virulent disseminated stages of disease. Cancer. 1984 54 657-662. [Pg.333]

Note-. Aetiological factors linked to the development of thyroid cancer. MEN2A, multiple endocrine neoplasia type 2A MEN2B, multiple endocrine neoplasia type 2B MTC, medullary thyroid carcinoma. [Pg.515]

In patients with thyroid cancer, Komorowski et al. (K8) reported that plasma MMP-2 levels were higher (605 82 ng/ml versus 149 44 ng/ml), along with TIMP-2 (114 7 ng/ml versus 61 9 ng/ml) than in controls in contrast, lower levels of MMP-1 (0.70 0.42 ng/ml versus 3.87 0.53 ng/ml) were reported. Increased levels of plasma MMP-3 and MMP-9 were found in patients with medullary thyroid carcinoma. [Pg.56]

In most cases, neoplasia is an individual disease occurring sporadically. However, 5-15% of tumors (in certain types of cancer up to 25% e.g. medullary thyroid carcinoma) is inherited due to a germ line mutation in a tumor suppressor gene or a proto-oncogene. It is noteworthy to mention that genes mutated in inherited cancer syndromes could also play a role in somatic cardnogenesis. [Pg.85]

P.M. et al. (2001) Circulating calcitonin and carcinoembryonic antigen m-RNA detected by RT-PCR as tumor markers in medullary thyroid carcinoma. Br J Cancer, 85, 154-1550. [Pg.270]

Schott M, Feldkamp J, Klucken M, Kobbe G, Scherbaum WA, Seissler J. Calcitonin-specific antitumor immunity in medullary thyroid carcinoma following dendritic cell vaccination. Cancer Immunol Immunother 2002 51 663—668. [Pg.483]

The RET proto-oncogene located on chromosome 10 codes for a transmembrane tyrosine kinase. Mutations at codon 634 are directly associated with multiple endocrine neoplasia type 2A and medullary thyroid carcinoma. If children are diagnosed to carry such a mutation, cancer can be prevented by removal of the thyroid gland. Accuracy and reliability of the diagnostic assay is critical here as in... [Pg.41]

Medulloblastomas Pheochromocytomas Medullary thyroid carcinomas Small-cell lung cancers Lung carcinoid tumors Pituitary adenomas Congenital mesoblastic nephroma Multiple myelomas T-cell malignant lymphomas Leukemias (AML)... [Pg.114]

SCLC small cell limg carcinoma, MTC medullary thyroid cancer... [Pg.47]

The amplification of thyroglobulin, thyroid peroxidase and TTF-1 mRNA can be a valuable sensitive method for the detection of micrometastases, minimal residual cancer cells and circulating tumor cells of papillary and follicular thyroid carcinoma. TTF-1 can be also used for the detection ofthyroid medullary carcinoma and different lung neoplasia derived from alveolar cells type II and Clara cells (mainly adenocarcinoma). The presence of circulating tumor cells is associated with poor prognosis and... [Pg.207]

Enolase is a glycolytic enzyme also known as phosphopyru-vate hydratase. Neuron-specific enolase (NSE) is the form of enolase found in neuronal tissue and in the cells of the diffuse neuroendocrine system and the amine precursor uptake, and decarboxylation (APUD) tissue. NSE is found in tumors associated with the neuroendocrine origin, including small cell lung cancer (SCLC), neuroblastoma, pheochromocytoma, carcinoid, medullary carcinoma of the thyroid, melanoma, and pancreatic endocrine tumors. [Pg.756]

Kovacs CS, Mase RM, Kovacs K, et al. Thyroid medullary carcinoma with thyroglobulin immunoreactivity in sporadic multiple endocrine neoplasia type 2-B. Cancer. 1994 74 928-932. [Pg.250]

Sikri KL, Varndell IM, Hamid QA, et al. Medullary carcinoma of the thyroid An immunocytochemical and histochemical study of 25 cases using 8 separate markers. Cancer. 1985 56 2481-2491. [Pg.333]

Note-. PC, papillary carcinoma FC, follicular carcinoma UC, undifferentiated carcinoma MC, medullary carcinomas TL, thyroid lymphoma NA, not applicable (TL none in males and before salt iodination, MC two and three cases before and after prophylaxis, respectively). Thyroid cancer by type, mean age and gender before (1958-1972) (I) and after (1985-2003) (II) salt iodization in the province of Salta, Argentina. [Pg.516]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...