Colloid carcinoma

Colloidal activated carbon bound to methotrexate, following intratumoral administration of a weekly dose of 30 mg/kg, has also been found to be effective against human colon carcinoma (LoVo) implanted into the backs of BALB/c nude mice (237). 

Importantly, other mucinous neoplasms with morphologic intestinal features, the colloid carcinoma of the lungi45 with goblet cells (100%), and a subset of ovarian mucinous carcinomas (64%) are CDX2 positive. The majority of the colloid lung tumors are TTF-1 positive, a feature that allows distinction from metastatic colorectal mucinous carcinoma. Ovarian mucinous carcinomas may be separated from gastrointestinal mucinous carcinomas by virtue of typical immunostaining for CK7 in the ovarian tumors. 

Other CDX2-I- tumors include colloid lung carcinomas (also positive for TTF-1) and ovarian mucinous carcinomas (CK7-I- with CK20 expression weaker than CK7). 

Rossi G, Murer B, Cavazza A, et al. Primary mucinous (so-called colloid) carcinomas of the lung a clinicopathologic and immunohistochemical study with special reference to CDX-2 homeobox gene and MUC2 expression. Am J Surg Pathol. 2004 28 442-452. 

CDX2 expression may be seen in primary mucinous "colloid" pulmonary carcinomas. They may also express CK20 and lack CK7 and TTF-1. Clinical correlation and Imaging may be critically necessary In these situations. 

FIGURE 15.8 Strong and often diffuse intracytoplasmic MUC2 labeling is specific for colloid carcinoma. 

FIGURE 15.9 Colloid carcinomas also express CDX2 diffusely. 

FIGURE 15.10 In contrast to MUC2, intracytoplasmic CEA labeling is much weaker in colloid carcinoma however, there is strong CEA labeling in the stroma-facing surface of the cells. 

Invasive carcinoma associated with villous/intestinal type, which is typically colloid carcinoma, also expresses MUC2 and CDX2 but not MUCl. In addition, villous/ intestinal-type papillae are positive for MUC5AC and negative for MUC6. > > > ... 

Pure mucinous (colloid) carcinomas as seen in the breast, skin, or pancreas2 2 practically nonexistent in the gallbladder however, mucinous carcinomas as described in the colon, in which the mucinous pattern constitute 50% to 90% of the tumor do occur. ... 

Adsay NV, Pierson C, Sarkar F, et al. Colloid (mucinous non-cystic) carcinoma of the pancreas. Am J Surg Pathol. 2001 25 26-42. 

Khalifeh I, Basturk O, Zamboni G, et al. Villous-intestinal differentiation and progression to colloid carcinoma, characteristic of a major subset of IPMNs, are not featrrres of mucinous cystic neoplasms. Mod Pathol. 2005 18 281A. 

Tickoo SK, Amin MB, Zarbo RJ. Colloidal iron staining in tenal epithelial neoplasms, including chromophobe renal cell carcinoma emphasis on technique and patterns of staining. Am J Surg Pathol. 1998 22 419. 

Fig.4.26a-d. Advanced breast-biopsy instrumentation specimen radiographs infracentimetric nonpalpable breast carcinomas resected with tumor-free margins, a A 6-mm invasive ductal carcinoma, b A 6-mm colloid carcinoma, c A 8-mm tubular carcinoma, d A 5-mm ductal carcinoma in situ... 

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