Mucinous cystic neoplasm

FIGURE 15.13 Progesterone receptors are expressed In the ovarian-like stroma cells and may be used to confirm the diagnosis in equivocal cases of mucinous cystic neoplasms. 

Mucinous cystic neoplasms (MCNs) are mucinous/ductal type neoplasia and thus the epithelial cells are positive for CKs, as well as for EMA, CA19-9, and CEA. 

This adenoma represents the biliary counterpart of pancreatic mucinous cystic neoplasm (see Pancreas earlier for details... 

Yanagisawa A, Kato Y, Ohtake K, et al. c-Ki-ras point mutations in ductectatic-type mucinous cystic neoplasms of the pancreas./pn J Cancer Res. 1991 82 1057-1060. 

Sarr MG, Carpenter HA, Prabhakar LP, et al. Clinical and pathologic correlation of 84 mucinous cystic neoplasms of the pancreas can one reliably differentiate benign from malignant (or premalignant) neoplasms Ann Surg. 2000 231 205-212. 

Thompson LD, Becker RC, Przygodzki RM, et al. Mucinous cystic neoplasm (mucinous cystadenocarcinoma of low-grade malignant potential) of the pancreas a clinicopathologic study of 130 cases. Am J Surg Pathol. 1999 23 1-16. 

Luttges J, Peyerabend B, Buchelt T, et al. The mucin profile of noninvasive and invasive mucinous cystic neoplasms of the pancreas. Am J Surg Pathol. 2002 26 466-471. 

Ohta T, Nagakawa T, Pttkushima W, et al. Immrmohistochemi-cal study of carcinoembryonic antigen in mucinous cystic neoplasm of the pancreas. Eur Surg Res. 1992 24 37-44. 

Yu HC, Shetty J. Mucinous cystic neoplasm of the pancreas with high carcinoembryonic antigen. Arch Pathol Lab Med. 1985 109 375-377. 

Khalifeh I, Basturk O, Zamboni G, et al. Villous-intestinal differentiation and progression to colloid carcinoma, characteristic of a major subset of IPMNs, are not featrrres of mucinous cystic neoplasms. Mod Pathol. 2005 18 281A. 

Khalifeh I, Qureshi F, Jacques S, et al. The nature of ovarian-like mesenchyme of pancreatic and hepatic mucinous cystic neoplasms A recapitulation of the periductal fetal mesenchme . Mod Pathol. 2004 17 304A. 

Wilentz RE, Albores-Saavedra J, Hruban RH. Mucinous cystic neoplasms of the pancreas. Semin Diagn Pathol. 2000 17 31-... 

Jimenez RE, Warshaw AL, Z Gragjen K, et al. Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy. Ann Surg. 1999 230 501-509 discussion 509-511. 

Kim SG, Wu TT, Lee JH, et ak Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous mi-crocystic adenoma of pancreas. Mod Pathol. 2003 16 1086-1094. 

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