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Carcinogenicity dermatitis

Methanol is not classified as carcinogenic, but can be acutely toxic if ingested 100—250 mL may be fatal or result in blindness. The principal physiological effect is acidosis resulting from oxidation of methanol to formic acid. Methanol is a general irritant to the skin and mucous membranes. Prolonged skin contact with methanol vapor or Hquid can cause dermatitis. Methanol vapor can cause eye and respiratory tract irritation, nausea, headaches, and dizziness. [Pg.280]

Cobalt compounds can be classified as relatively nontoxic (33). There have been few health problems associated with workplace exposure to cobalt. The primary workplace problems from cobalt exposure are fibrosis, also known as hard metal disease (34,35), asthma, and dermatitis (36). Finely powdered cobalt can cause siUcosis. There is Htfle evidence to suggest that cobalt is a carcinogen in animals and no epidemiological evidence of carcinogenesis in humans. The LD q (rat) for cobalt powder is 1500 mg/kg. The oral LD q (rat) for cobalt(II) acetate, chloride, nitrate, oxide, and sulfate are 194, 133, 198, 1700, 5000, and 279 mg/kg, respectively the intraperitoneal LD q (rat) for cobalt(III) oxide is 5000 mg/kg (37). [Pg.379]

The past experience of the dyestuff industry in its use of dye intermediates such as ( -naphthyl amine and benzidine (4), known human bladder carcinogens (334—343), have led to studies as to whether or not handlers of dyes are exposed to medical ha2ards such as cancer, dermatitis, and other disorders (344-360). [Pg.386]

The levels of antifeedants can be raised safely only in plants such as forest trees or fiber crops, not in food plants for humans or livestock. Such problems have arisen inadvertently. For instance, a new insect-resistant potato cultivarhad to be withdrawn from the market because it contained high levels of the carcinogens solanine and chaconine (Renwick etal, 1984). In another example, an insect-resistant celery had 10 times the usual concentration of the carcinogen 8-methoxypsoralen (and related psoralens), which caused dermatitis in produce handlers (Seligman etal, 1987). [Pg.406]

Toxieology. Exposure to compounds of beryllium may cause dermatitis, acute pneumonitis, and chronic pulmonary granulomatosis (berylliosis) in humans. The compounds are carcinogenic in experimental animals and considered to be suspected human carcinogens. [Pg.81]

Toxicology. Formaldehyde is an irritant of the eyes and respiratory tract it causes both primary irritation and sensitization dermatitis at high levels it is carcinogenic in experimental animals and, although results are equivocal in humans, it is considered a suspected human carcinogen. [Pg.348]

Nickel (Ni) Lung carcinogen, contact dermatitis Food supply, workplace exposure... [Pg.125]

Elemental Be and its compounds are very poisonous by inhalation or intravenous route. Chronic inhalation of beryUium dusts or fumes can cause a serious lung disease, beryUiosis, after a latent period ranging from several months to many years. Inhalation of airborne dusts can also cause an acute disease manifested as dyspnea, pneumonitis and tracheobronchitis with a short latency period of a few days. Skin contact with soluble salts of the metal can cause dermatitis. Beryllium also is a carcinogen. There is sufficient evidence of its inducing cancer in animals and humans. [Pg.99]

In laboratory animals, TCDD administered in suitable doses has produced a wide variety of toxic effects, including a wasting syndrome (severe weight loss accompanied by reduction of muscle mass and adipose tissue), thymic atrophy, epidermal changes, hepatotoxicity, immunotoxicity, effects on reproduction and development, teratogenicity, and carcinogenicity. The effects observed in workers involved in the manufacture of 2,4,5-T (and therefore presumably exposed to TCDD) consisted of contact dermatitis and chloracne. In severely TCDD-intoxicated patients, discrete chloracne may be the only manifestation. [Pg.1223]

N.A. Croton oil.105 Oil is carcinogenic, can be fatal. For constipation, dysentery, biliary colic, intestinal obstructions, food poisoning, malaria, mastitis. Externally for warts, dermatitis, abscesses, boils. [Pg.194]

The biological effects of chromate are apparent in three main areas mutagenicity and carcinogenicity, an adverse immune response and the use of chromate in clinical chemistry to tag erythrocytes. The clinical use of chromate has recently been reviewed1441 and although reviews of the immune response to chromate are available1442 little is known of the chemistry involved this is surprising as chromate present in cement is a major cause of dermatitis. [Pg.947]

The most common deleterious effects of modem cosmetics are occasional allergic reactions and contact dermatitis. The highly toxic and/or carcinogenic azo or aromatic... [Pg.71]

Vapor may cause dizziness, nausea, and unconsciousness. Contact of liquid with skin may cause dermatitis or severe burns. Swallowing or absorption through skin leads to poisoning. Prolonged breathing of vapor may result in jaundice. Human carcinogen. [Pg.22]

Symptoms of exposure are gastroenteric distress, tremors, convulsions, fever, and dermatitis. Effects of chronic exposure are tumors, cancer, and dermatitis.3,4 Animal carcinogen. Reasonably anticipated to be a human carcinogen.5... [Pg.201]

Animal carcinogen.2-5 Factory workers may develop contact dermatitis.4 The characteristic acute toxic effect is methemyglobinemia. LD50 (oral, rat) 200 mg/kg4 LD50 (i.p., mouse) 500 mg/kg LD50 (oral, mouse) 300 mg/kg.5 Reasonably anticipated to be a human carcinogen.2... [Pg.232]

Dust irritates the skin, eyes, and mucous membranes.14 Animal carcinogen reasonably anticipated to be a human carcinogen.15 May cause dermatitis in sensitive individuals.1 TLV-TWA 1.5 mg/m3.16... [Pg.387]

Animal carcinogen. A single dose can often be carcinogenic. This compound is also both mutagenic and teratogenic. Reasonably anticipated to be a human carcinogen.1-3 It has been known to cause contact dermatitis. LD50 (oral, rat) 110 mg/kg.4... [Pg.409]

Because aromatic hydrocarbons are rapidly absorbed by the system, resulting in adverse effects, the worker must be aware of protective measures during handling. For instance, these compounds have caused defatting, skin dehydration, and dermatitis. Their affinity to blood-forming tissue and myelotoxic reaction prolonged exposure results in carcinogenicity. Further, these compounds have caused... [Pg.210]


See other pages where Carcinogenicity dermatitis is mentioned: [Pg.255]    [Pg.423]    [Pg.39]    [Pg.427]    [Pg.139]    [Pg.258]    [Pg.108]    [Pg.584]    [Pg.952]    [Pg.542]    [Pg.84]    [Pg.150]    [Pg.73]    [Pg.154]    [Pg.157]    [Pg.122]    [Pg.126]    [Pg.130]    [Pg.609]    [Pg.108]    [Pg.584]    [Pg.952]    [Pg.62]    [Pg.42]    [Pg.427]    [Pg.380]    [Pg.191]    [Pg.207]    [Pg.46]    [Pg.377]    [Pg.518]    [Pg.174]   
See also in sourсe #XX -- [ Pg.174 ]




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