Mammary epithelium

Sumantran, VN, Zhang, R, Lee, DS, and Wicha, MS, 2000. Differential regulation of apoptosis in normal versus transformed mammary epithelium by lutein and retinoic acid. Cancer Epidemiol Biomarkers Prev 9, 257-263. 

Mammary epithelium is very sensitive to hormonal stimulation. It is where proliferative events take place and where neoplastic transformation begins. 

Richards, J., Guzman, R., Yang, J., Nandi, S., and Konrad, M. (1980). Chemical carcinogenesis of mammary epithelium in cell culture, page 467 in Cell Biology of Breast Cancer, McGrath, C.M., Brennan, M.J., and Rich, M.A., Eds. (Academic Press, New York). 

Mammary epithelium Aortic endothelial cells Skin fibroblasts Ovarian cells... 

CA 15-3, CA 549, and CA 27.29 assays detect a high molecular weight glycoprotein mucin expressed by the mammary epithelium, known as episialin. The circulating episialin antigen is a heterogeneous molecule. CA 15-3, CA 549, and CA 27.29 assays detect similar yet different epitopes on the episialin. The main differences are the antibodies used for detection. They are used as markers for breast carcinoma. 

Oka, T., and Perry, J. W., Spermidine as a possible mediator of glucocorticoid effect on milk protein synthesis in mouse mammary epithelium in vitro. J. Biol. Chem. 249, 7647-7652 (1974). 

Epithelial membrane antigen (EMA) is one of several human milk fat globule proteins (HMEGPs) that are derived from the mammary epithelium. The HMEGPs... 

Petersen OW, VanDeuers B. Characterization of epithelial membrane antigen expression in human mammary epithelium by ultrastructural immunoperoxidase cytochemistry. J Histochem Cytochem. 1986 34 801-809. 

Cholesterol, a- and 3-epoxides were present in 45% of breast fluid specimens examined with a-isomer predominating. Epoxide levels tended to be higher in fluids with high cholesterol levels and in those taken from older women prompting researchers to speculate that benign breast disease and cancer could result (91). The nonlactating breast concentrates its secretions and thereby exposes the mammary epithelium to a-epoxide. 

Su Y, Shankar K, Rahal O, Simmen RCM (2011) Bidirectional signaling of mammary epithelium and stroma implications for breast cancer—preventive actions of dietary factors. J Nutr Biochem 22 605 11... 

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