Carcinogenesis experimental studies

Coggle, J.E. and J.P. Williams. 1990. Experimental studies of radiation carcinogenesis in the skin a review. Inter. Jour. Radiation Biol. 57 797-808. 

Heuper, W. C. (1955b). Experimental studies in metal carcinogenesis. J. Natl. Cancer Inst. 15 113. 

Hueper WC. 1958. Experimental studies in metal carcinogenesis. IX. Pulmonary lesions in guinea pigs and rats exposed to prolonged inhalation of powdered metallic nickel. Arch Pathol 65 600-607. 

For the agent, mixture or exposure circumstance being evaluated, the available data on end-points or other phenomena relevant to mechanisms of carcinogenesis from studies in humans, experimental animals and tissue and cell test systems are summarized within one or more of the following descriptive dimensions ... 

Grogan CH. 1957. Experimental studies in metal Carcinogenesis VIII. On the etiological factor in chromate cancer. Cancer 10 625-638. 

Grogan CH, Oppenheimer H. 1955. Experimental studied in metal carcinogenesis. V. Interaction of Cr(III) and Cr(VI) compounds with proteins. Arch Biochem Biophys 56 204-22E... 

HueperWC. 1955. Experimental studies in metal carcinogenesis. VII. Tissue reactions to parenterally introduced powdered metallic chromium and chromite ore. J Natl Cancer Inst 16 447-469. 

HueperWC, Payne WW. 1962. Experimental studies in metal carcinogenesis. X. Cancerigenic effects of chromite ore roast deposited in muscle tissue and pleural cavity of rats. Arch Environ Health 5 51-68. 

Hueper WC, Zuefle JH, Link AMetal. 1952. Experimental studies in metal carcinogenesis. II. Experimental uranium cancers in rats. Journal of the National Cancer Institute 13 291-305. 

Berenblum, I., and Shubik, P. (1949). An experimental study of the initiating state of carcinogenesis, and a re-examination of the somatic cell mutation theory of cancer. Br J Cancer 3(1), 109-118. 

In reviewing experimental studies dealing with L-tryptophan and carcinogenesis, it becomes apparent that L-tryptophan acts in most cases as a stimulatory agent in chemical carcinogenesis. However, in some cases, it appears to act in an inhibitory manner. In attempting to possibly explain each of the above actions of L-tryptophan, the following considerations should be reviewed. 

In searching for an explanation for how the ingestion of L-tryptophan may be involved in the process of chemical carcinogenesis in experimental studies, several studies have concluded that L-tryptophan acts as a co-carcinogen or promoter.250 252 275 Some of the following effects or actions of L-tryptophan may influence such processes in carcinogenesis. 

A literature review of animal experimental studies with tryptophan and carcinogenesis, particularly involving bladder and liver, indicates that tryptophan alone does not induce tumors but is capable of acting in many cases as a promoting agent in chemical carcinogenesis. Whether this effect is due to tryptophan alone or to tryptophan metabolites is not clear. In the induction of bladder cancer, tryptophan metabolites are clearly implicated. 

Coggle JE, Williams JP. 1990. Experimental studies of radiation carcinogenesis in the skin A review. 

On the contrary, transplacental carcinogenesis of many chemicals is well documented in many experimental studies. Moreover, it has been proved as early as in the 1960s that much lower doses are effective for an in utero exposure than for an exposure in adults... 

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