Carbenicillin sodium

The elements present in a host of pharmaceutical substances are determined quantitatively by atomic absorption spectroscopy, for example Pd in carbenicillin sodium Cu, Pb and Zn in activated charcoal Fe in ascorbic acid Ag in cisplatin Ph and Zn in copper sulphate Zn in glucogen Zn in insulin Pb in oxprenolol hydrochloride Ni in prazosin hydrochloride Zn in sodium sulphite heptahydrate, and Cd and Pb in zinc oxide. 

Procedure Moisten 1 g of carbenicillin sodium in a silica crucible with 2 ml of sulphuric acid. Heat, gently at first, then more strongly until all carbon is removed and a white ash is obtained. Allow to cool and add 5 ml of a mixture of nitric acid and hydrochloric acid and evaporate to dryness on a water-bath. Add 3 ml of hydrochloric acid, warm to dissolve and add sufficient water to produce 25 ml. 

AAS is used in a number of limit tests for metallic impurities, e.g. magnesium and strontium in calcium acetate palladium in carbenicillin sodium and lead in bismuth subgallate. It is also used to assay metals in a number of other preparations zinc in zinc insulin suspension and tetracosactrin zinc injection copper and iron in ascorbic acid zinc in acetylcysteine lead in bismuthsubcarbonate silver in cisplatinum lead in oxyprenolol aluminium in albumin solution and calcium, magnesium, mercury and zinc in water used for diluting haemodialysis solutions. 

In Older to improve the poor oral absorption of carbenicillin [4697-36-3] a bpophilic rndanyl ester has been formulated, Geocillin [33331-88-3] (5). Prednisolone [30-24-8] a steroid, is derivatized to its C-21 hemisuccinate sodium salt (6) to make it extremely water-soluble (108). 

Sodium-containing drugs (e.g., carbenicillin disodium, ticarcillin disodium)... 

Ampicillin sodium Amylobarbitone Betamethasone Betamethasone valerate Carbenicillin disodium Chloroquine phosphate Chloroquine sulphate Cemetidine Clofazimine Clofibrate Clonidine... 

Carbenicillin Carbenicillin, [25 -(2a,5a,6j3)]-3,3-dimethyl-7-oxo-6-(2-carboxy-2-phenylacetamido)-4-thia-l-azabicyclo[3.2.0]-heptan-2-carboxylic acid (32.1.1.32), is synthesized by direct acylation of 6-APA in the presence of sodium bicarbonate by phenylmalonic acid monobenzyl ester chloride, which forms the benzyl ester of carbenicillin (32.1.1.31), the hydrogenolysis of which using palladium on carbon or calcium carbonate as catalyst gives the desired product (32.1.1.32) [51-58]. 

Tablets, film-coated 382 mg carbenicillin (118 mg indanyl sodium ester) Rx)...

Incompatibilities Do not mix IV minocycline before or during administration with any solutions containing the following Adrenocorticotropic hormone (ACTH), aminophylline, amobarbital sodium, amphotericin B, bicarbonate infusion mixtures, calcium gluconate or chloride, carbenicillin, cephalothin sodium, cefazolin sodium, chloramphenicol succinate, colistin sulfate, heparin sodium, hydrocortisone sodium succinate, iodine sodium, methicillin sodium, novobiocin, penicillin, pentobarbital, phenytoin sodium, polymyxin, prochlorperazine, sodium ascorbate, sulfadiazine, sulfisoxazole, thiopental sodium, vitamin K (sodium bisulfate or sodium salt), whole blood. 

Carbenicillin indanyl sodium is an antipseudomonal penicillin formulated for oral administration. The drug achieves negligible carbenicillin concentrations in the urine of patients with renal failure. Consequently, carbenicillin is not appropriate for patients with renal failure. In patients with normal renal function, however, carbenicillin indanyl sodium is used to treat urinary tract infections caused by P. aeruginosa, Proteus spp., and Escherichia coli. 

Rx amoxicillin, ampicillin, bacampicillin, carbenicillin, cloxacillin, dicloxacillin, flucloxacillin, methicillin, mezlocillin, nafcillin, oxacillin, penicillin G benzathine, penicillin G potassium, penicillin Vpotassium, piperacillin, pivampicillin, pivme-cillinam, ticarcillin Penicillin and beta-lactamase inhibitors amoxicillin/ clavulanate potassium, ampicillin/sulbactam sodium, piperacillin sodium/ tazobactam sodium, ticarcillin disodium/clavulanate potassium Chemical Class Penicillin, natural... 

Ampicillin/sulbactam sodium (generic, Unasyn)2 Parenteral 1, 2 g ampicillin powder to reconstitute for IV or IM injection Carbenicillin (Geocillin)... 

Penicillins have several properties that are characteristic of /i-lactam antibiotics. They are obtained in relatively pure form as off-white, tan, or yellow freeze-dried or spray-dried solids that are usually amorphous. Alternatively they are sometimes obtained as crystalline solids, often as hydrates. Penicillins do not usually have sharp melting points, but decompose upon heating to elevated temperatures. Most natural members have a free carboxyl group and commercial preparations are generally either supplied as salts, most frequently as sodium salts, or in zwitterionic form as hydrates, e.g.. amoxicillin trihydrate. The acid strength of the carboxyl group in aqueous solution varies from pAT = 2.73 for oxacillin to p= 3.06 for carbenicillin. 

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