Capsules administration

In 1981, Chinese Restaurant Asthma was reported following capsule administration of MSG to several asthmatics (37). However, the researchers failed to account for other allergens to which the subjects could have been exposed and did not utilize the scientific practice of a "control" substance which would have helped to determine if glutamate triggered this response. In a double-blind crossover study, chronic asthmatics were challenged with MSG or a placebo. No decrease in pulmonary function was observed (39). 

Controlled/Extended/Sustained-release (CFt/EFt/SR) Swallow whole do not break, chew, or crush. See below for SR capsule administration. 

Absorption/Distribution - Loperamide is 40% absorbed after oral administration and does not penetrate well into the brain. Peak plasma levels occur approximately 5 hours after capsule administration, 2.5 hours after liquid administration and are similar for both formulations. 

Capsules The oral bioavailability of itraconazole is maximal when itraconazole capsules are taken with a full meal. Peak plasma levels are observed 3.3 hours (fasting) and 4 hours (with food) following capsule administration. 

Buss N, Snell P, Bock J, Hsu A, Jorga K. Saquinavir and ritonavir pharmacokinetics following combined ritonavir and saquinavir (soft gelatin capsules) administration. Br J Clin Pharmacol 2001 52(3) 255-64. 

Polymer—polymer iacompatibiHty encapsulation processes can be carried out ia aqueous or nonaqueous media, but thus far have primarily been carried out ia organic media. Core materials encapsulated tend to be polar soHds with a finite degree of water solubiHty. EthylceUulose historically has been the sheU material used. Biodegradable sheU materials such as poly(D,L-lactide) and lactide—glycoHde copolymers have received much attention. In these latter cases, the object has been to produce biodegradable capsules that carry proteias or polypeptides. Such capsules tend to be below 100 p.m ia diameter and are for oral or parenteral administration (9). 

The oral route is the most frequent route of drug administration and rarely causes physical discomfort in patients. Oral drug forms include tablets, capsules, and liquids. Some capsules and tablets contain sustained-release drag s, which dissolve over an extended period of time. Administration of oral dru is relatively easy for patients who are alert and can swallow. 

Administering Oral Nitroglycerin. Nitroglycerin is also available as oral tablets tiiat are swallowed. The nurse gives tiiis form of nitroglycerin to die patient whose stomach is empty, unless the primary health care provider orders otherwise. If nausea occurs after administration, die nurse notifies die primary healdi care provider. Taking die tablet or capsule widi food may be ordered to relieve nausea The sustained released preparation may not be crushed or chewed. 

Capsules— These are primarily intended for oral administration and are solid preparations with hard or soft shells comprised of gelatin or hydrox-ypropyl methyl cellulose and small amounts of other ingredients such as plasticizers, fillers, and coloring agents. Their contents may be powders, granules, pellets, liquids, or pastes. 

This pigment is recognized by the U.S. Food and Drug Administration (21 Code of Federal Regulations, Part 73) as a color additive exempted from certification (Subpart A, Foods, Section 73.35, Astaxanthin). Formulations containing astaxanthin include soft gelatin capsules containing 100 mg equivalents of total carotenoids, a skin care... 

More definitive diagnostic tests include endoscopy (via endoscope or Pillcam ESO capsule), 24-hour ambulatory pH monitoring, diagnostic proton pump inhibitor (PPI) administration, or esophageal manometry. 

Plasma levels of diisopropyl methylphosphonate were measured in a single lactating Jersey cow after the sixth day of diisopropyl methylphosphonate oral administration (10 mg/kg/day) by gelatin capsule (Ivie 1980). For the first 5 days the cow was given unlabeled compound and fed hay ad libitum. The diisopropyl methylphosphonate administered on the 6th day was labeled with carbon 14. Based on measurements of label in the plasma, absorption in the cow paralleled that in rats and dogs, with the highest concentration detected in the plasma at 2 hours after administration. 

In all cases a connective tissue encapsulation of the injected phases was found, and, in most cases, some of the phase remained. In a few animals there were signs of irritation, either in the connective tissue capsule or in the surrounding tissue. Moreover, injections of the lamellar phase, which swell to the cubic phase in vivo, seemed to be slightly more irritating than injections of the fully swelled cubic phase, most probably due, in the former case, to dehydration of the surrounding tissue. However, no difference was found between sc and im administration. It should be noted that the monoolein used was not of pharmaceutical grade. 

Fig. 4 Mean cumulative urinary excretion of nitrofurantoin after oral administration of a 100-mg macrocrystalline capsule of fasting (O) and nonfasting ( ) subjects and a 100-mg microcrystalline tablet to fasting ( ) and nonfasting ( ) subjects. Vertical bars represent standard errors of the mean. (From Ref. 7.).

In-depth discussions of the anatomy of the eye and adnexa have been adequately covered elsewhere in the pharmaceutical literature [13-17] and in recent texts on ocular anatomy. Here a brief overview is presented of the critical anatomical features that influence the nature and administration of ophthalmic preparations. In this discussion, consideration will be given primarily to drugs applied topically, that is, onto the cornea or conjunctiva or into the palpebral fornices. Increasingly, drugs are being developed for administration by parenteral-type dosage forms subconjunctivally, into the anterior and posterior chambers, the vitreous chamber, Tenon s capsule, or by retrobulbar injection. 

Comparative bioavailability data are discussed where a number of different dosage forms/routes of administration have been used during the development process, e.g., tablets, capsules, oral solutions, granules, and injections. 

Chewable tablets and sprinkle capsule formulations have been very well received by both patients and their parents for use in children with full dentition (older than 3 years, [75-77]. This is potentially a very fruitful area for future research and development. Pharmaceutical preparations developed for administration to young children need to have consistent bioavailability when administered with food [78]. 

G Gwinup, AN Elias, ES Domurat. Insulin and C-peptide levels following oral administration of insulin in intestinal-enzyme protected capsules. Gen Pharmacol 22 143-246, 1991. 

FDA. 1996. Tin-coated lead foil capsules for wine bottles. U. S. Food and Drug Administration. Code of Federal Regulations. 21 CFR 189.301. 

Oral (PO = per os) By the mouth. Oral administration is the most common route employed for a variety of dosage forms tablets, capsules, liquids, suspensions. The major site of absorption is the small intestine. Alcohol is absorbed from the stomach. 

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