Cyclodextrin concentration capillary electrophoretic separation

Rawjee, YY, Williams, R.L., Buckingham, L.A., Vigh, G Effects of pH and hydroxypropyl fS-cyclodextrin concentration on peak resolution in the capillary electrophoretic separation of the enantiomers of weak bases. J. Chromatogr. 1994, 688, 273-282. 

Lin et al. [95] used capillary electrophoresis with dual cyclodextrin systems for the enantiomer separation of miconazole. A cyclodextrin-modified micellar capillary electrophoretic method was developed using mixture of /i-cyclodextrins and mono-3-0-phenylcarbamoyl-/j-cyclodextrin as chiral additives for the chiral separation of miconazole with the dual cyclodextrins systems. The enantiomers were resolved using a running buffer of 50 mmol/L borate pH 9.5 containing 15 mmol/L jS-cyclodextrin and 15 mmol/L mono-3-<9-phcnylcarbamoyl-/j-cyclodextrin containing 50 mmol/L sodium dodecyl sulfate and 1 mol/L urea. A study of the respective influence of the /i-cyclodcxtrin and the mono-3-(9-phenylcarbamoyl-/i-cyclodextrin concentration was performed to determine the optical conditions with respect to the resolution. Good repeatability of the method was obtained. 

Rawjee, Y.Y., Stark, D.U., Vigh, G. Capillary electrophoretic chiral separations with cyclodextrin additives I. acids Chiral selectivity as a function of pH and the concentration of P-cyclodextrin for fenoprofen and ibuprofen. J. Chromatogr. 1993, 635, 291-306. 

YY Rawjee, RL Williams, G Vigh. Capillary electrophoretic chiral separations using /3-cyclodextrin as resolving agent. II. Bases chiral selectivity as a function of pH and the concentration of / -cyclodextrin. J Chromatogr A 652 233-245, 1993. 

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