Cancer selenium supplements

Prostate cancer effect. Saw palmetto, vitamin E, and selenium supplements were used by 26.5% of the questioned men diagnosed with prostate cancer . PC-SPES, an herbal mixture of chrysanthemum, isatis, licorice, Ganoderrm lucidum, Panax pseudo-ginseng, Rabdosia rubescens, saw palmetto. 

Reid ME, Duffield-Lillico AJ, Garland L, etal. Selenium supplementation and lung cancer incidence an update of the Nutritional Prevention Cancer Trial. Cancer Epidemiol Biomark Prev 2002 11 1285-1291. 

Clark, L., Combs, G., Turnbull, B, Slate, E Chalker, D., Chow, J, Davis, L-, Gtover, R., Graham, G-, Gross, E., Krongrad, A., Lesher, J., Park, H-, Sanders, B., Smith, C., Taylor, J.R, (1996), Effects of selenium Supplementation for cancer prevention in patients with carcinoma of the skin. jAMA 276,1957-1963. 

Selenium, an essential micronutrient for plants, animals and microorganisms, has a direct impact on human health and environmental safety. Thus, Se supplementation of populations with low or deficient Se intakes may improve health, and supplementation of Se to populations with adequate intakes may reduce the risk of cancer. Selenium levels in the body are relevant for protection against chronic degenerative, neurological or neoplastic diseases. 

It now seems likely that selenium supplementation above the minimum dietary requirement has a role in cancer prevention, particularly in relation to prostatic cancer. The mechanism is not established, but in selenium-adequate subjects the excess selenium may produce a low molecular weight methylated selenium compound that has chemopre-ventive properties. A large selenium and vitamin E cancer prevention study, known as the Selenium and Vitamin E Cancer Prevention Trial (SELECT) study, will carry out controlled trials on more than 32,000 men to establish if there is a beneficial effect. ... 

Clark LC, Combs GF, Jr., Turnbull BW, Slate EH, Chalker DK, Chow J et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. 

Duffield-Lillico AJ, Slate EH, Reid ME, et al, and Nutritional Prevention of Cancer Study Group. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst 2003 95 1477-1481. 

Clark LC, Dalkin B, Krongrad A, et al. 1999. Decreased incidence of prostate cancer with selenium supplementation Results of a double-blind cancer prevention trial. J Am Nutraceut Assoc 2(1) 14-18. 

Ip C. 1981. Prophylaxis of mammary neoplasia by selenium supplementation in the initiation and promotion phases of chemical carcinogenesis. Cancer Res 41 4386-4390. 

Ip C. 1986. Interaction of vitamin C and selenium supplementation in the modification of mammary carcinogenesis in rats. J Natl Cancer Inst 77 299-303. 

Ip C, Hayes C. 1989. Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection. Carcinogenesis 10(5) 921-925. 

A14. Duffield-Lillico, A.J., M.E. Reid, B.W. Turnbull, G.F. 20A31. Combs, E.H. Slate, L.A. Fischbach, J.R. Marshall, and L.C. Clark Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial A summary report of the Nutritional Prevention of Cancer Trial Cancer Epid. 

Reid, M.E., Duffield-Lillico, A.J., Garland, L., Turnbull, B.W., Clark, L.C., and Marshall, J.R., Selenium supplementation and lung cancer incidence An update of the nutritional prevention of cancer trial. Cancer Epidemiol. Biomar. Prevent., 11, 1285-1291, 2002. 

Algotar AM, Stratton MS, Ahmann FR, Ranger-Moore J, Nagle RB, Thompson PA, et al. Phase 3 dinical trial investigating the effect of selenium supplementation in men at high-risk for prostate cancer. Prostate 2013 73(3) 328-35. 

As a constituent of selenoproteins, selenium has structural and enzymatic roles, e.g. as an antioxidant or catalyst. In addition to these enzymatic functions, selenium has some important health effects in relation to immune response and cancer prevention. There is growing evidence that selenium intakes higher than the dietary reference intake of 55 pg/day in combination with other antioxidants are associated with reduced cancer risk. " CE coupled to ICP-MS has been applied to investigate selenium speciation, particularly selenoamino acids, which are the principal dietary form of selenium. Today, there are several commercial nutritional selenium supplements available. Mounicou et al. have investigated selenium speciation in selenium-containing nutritional supplements by CE-ICP-MS, especially in selenium-enriched yeast... 

A few trials have suggested that selenium supplementation may have a protective effect on liver cancer in high-risk groups living in low-selenium areas. The provision of selenium-fortified salt to a town in Qidong, China, with high rates of primary liver cancer, reduced the incidence of this cancer by 35% compared with towns that did not receive this intervention (Table 3). Trials have also demonstrated the incidence of liver cancer to be... 

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