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Cancer inflammatory disease

The phytochemical investigations of Comus species revealed that their fruits are rich in bioactive compoimds such as polyphenols, anthocyanins, flavonoids, tannins, iridoids, triterpenoids, fatty acids, ascorbic acid and minerals. For many years they have been used in traditional and folk medicine to treat diabetes, liver and kidney diseases, gastrointestinal disorders, fever, pain and many others. Modem pharmaceutical studies indicated that Comus spp. fruits exhibit therapeutic effects on diabetes, cancer, inflammatory diseases, cardiovascular disorders or obesity, especially due to their high antioxidant activity. They also have notable beneficial effects on hepatoprotection, hyperlipidemia, neuroprotection and inhibiton of bacteria and vimses. [Pg.181]

Receptor tyrosine kinases (RTKs) have been implicated as therapeutic targets for the treatment of human diseases including cancers, inflammatory diseases. A series of Pyrrolo [3,2-c] pyridine-4-one 2-indolinone derivatives as tyrosine kinase inhibitors were designed and synthesized. They were found to inhibit the tyrosine kinase activity associated with vascular endothelial growth factor receptor 2(VEGF-R2). Their biological evaluation results and structure-activity relationship will be discussed. [Pg.188]

Thus, our attention should shift from the concern of potential adverse effects to the health benefits imparted by hormonal contraceptives. The use of oral contraceptives for at least 12 months reduces the risk of developing endometrial cancer by 50%. Furthermore, the risk of epithelial ovarian cancer in users of oral contraceptives is reduced by 40% compared with that on nonusers. This kind of protection is already seen after as little as 3-6 months of use. Oral contraceptives also decrease the incidence of ovarian cysts and fibrocystic breast disease. They reduce menstrual blood loss and thus the incidence of iron-deficiency anemia. A decreased incidence of pelvic inflammatory disease and ectopic pregnancies has been reported as well as an ameliorating effect on the clinical course of endometriosis. [Pg.392]

These compounds represent only some of the efforts being made to target the TLRs and their signalling pathways. Targeting TLRs holds great promise in the effort to find new therapies for infectious, allergic and inflammatory diseases, and cancer. [Pg.1212]

Taking the contraceptive hormones provides health benefits not related to contraception, such as regulating the menstrual cycle and decreased blood loss, and incidence of iron deficiency anemia, and dysmenorrhea Health benefits related to the inhibition of ovulation include a decrease in ovarian cysts and ectopic pregnancies. hi addition, there is a decrease in fibrocyctic breast disease, acute pelvic inflammatory disease endometrial cancer, ovarian cancer, maintenance of bone density, and symptoms related to endometriosis in women taking contraceptive hormones. Newer combination contraceptives such as norgestimate and ethinyl estradiol... [Pg.547]

Wiseman H, Halliwell B Damage to DNA by reactive oxygen and nitrogen species role In Inflammatory disease and progression to cancer. BlochemJ 1996 313 17. [Pg.497]

There is now considerable evidence suggesting a role for free radicals in the pathogenesis of inflammatory diseases and in the development of cancer. However, the effect of benefit from specific antioxidants in human disease remains to be established. Until this is done, the question of whether free radicals are yet just another inflammatory mediator, or whether their role is more central to the understanding of disease, remains open. [Pg.160]

In addition to their beneficial effects, some medications may actually cause cellular injury and disease. An example of this phenomenon involves nonsteroidal anti-inflammatory drugs (NSAIDS). These drugs include aspirin (a derivative of salicylic acid), ibuprofen (arylpropionic acid, Advil ), and acetaminophen (para-aminophenol derivative, Tylenol ). Because of their beneficial pharmacological effects, consumption of these agents has increased significantly in recent years. NSAIDS have the ability to treat fever, pain, acute inflammation, and chronic inflammatory diseases such as arthritis. They are also used prophylactically to prevent heart disease, stroke, and colon cancer. [Pg.292]

Noncontraceptive benefits of OCs include decreased menstrual cramps and ovulatory pain decreased menstrual blood loss improved menstrual regularity increased hemoglobin concentration improvement in acne reduced risk of ovarian and endometrial cancer and reduced risk of ovarian cysts, ectopic pregnancy, pelvic inflammatory disease, and benign breast disease. [Pg.339]

Cervical intraepithelial neoplasia or cervical cancer Pelvic inflammatory disease... [Pg.345]

Women using DMPA have a lower incidence of Candida vulvovaginitis, ectopic pregnancy, pelvic inflammatory disease, and endometrial and ovarian cancer compared to women using no contraception. The median time to conception from the first omitted dose is 10 months. [Pg.352]

Whereas initially the focus on antibody-based therapies was on cancer, anti-TNFa antibodies in particular have recently proven powerful in the therapy of chronic inflammatory diseases such as inflammatory bowel disease and rhemnatoid arthritis [71], These antibodies complex serum TNFa, the clinical benefit to RA patients most likely being the reduction of pro-inflammatory IL-6 and acute phase protein levels [9], Although they are directed against soluble proteins and as such will not serve as a drug carrier, they do show that targeted, i.e. selective, interference with a specific molecule or process can have a powerful effect without significant concomitant toxicity. [Pg.14]

In general, when the cells of the endothelium in the lungs are the target cells of interest (see Chapters 7 and 9 on aspects of targeting drugs to endothelium in inflammatory diseases and cancer, respectively), systemic administration seems the route of choice. Bronchial epithelium on the other hand can more easily be reached via the pulmonary route. The accessibility of other cells in the lungs is most hkely governed by disease conditions, factors that can affect epithehal permeability and vascular permeability, and others as described earher. [Pg.83]


See other pages where Cancer inflammatory disease is mentioned: [Pg.118]    [Pg.146]    [Pg.567]    [Pg.909]    [Pg.106]    [Pg.9]    [Pg.567]    [Pg.539]    [Pg.118]    [Pg.146]    [Pg.567]    [Pg.909]    [Pg.106]    [Pg.9]    [Pg.567]    [Pg.539]    [Pg.171]    [Pg.354]    [Pg.889]    [Pg.899]    [Pg.975]    [Pg.1091]    [Pg.159]    [Pg.457]    [Pg.293]    [Pg.212]    [Pg.828]    [Pg.292]    [Pg.503]    [Pg.189]    [Pg.5]    [Pg.71]    [Pg.72]    [Pg.63]    [Pg.71]    [Pg.4]    [Pg.175]    [Pg.186]   
See also in sourсe #XX -- [ Pg.567 ]

See also in sourсe #XX -- [ Pg.567 ]




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