Cancer, human environment, role

Goyer RA, Cherian MG. Role of metallothionein in human placenta and rats with cadmium exposure. In Cadmium in the human environment toxicity and carcinogenicity. Nordberg G, Herber R,Alessio E (editors). International Agency for Research on Cancer (lARC) Scientific Publications, Vol 118, Eyon 1992 p. 239-247. 

The T -nucleotide radical is a very important species in biology. (or HOO) and 102 play important roles in human immunity for defense against viruses. However, these reactive radicals also induce cancer, since they rapidly react with DNA, RNA, and peptides. So, these oxygen-centered radical species not only kill viruses, but also induce cancer, depending on the environment or field of these radicals generated. An important... 

First, although there is substantial evidence that many cancers are primarily associated with so-called lifestyle factors , the natural environment including viruses, and even genetics, we certainly cannot rule out some role for industrial chemicals. Moreover, chemicals can cause many other types of adverse health effects about which we do not have significant explanations of any type. Until we have evidence to rule out a significant role for industrial pollutants in human reproductive disorders, diseases of the nervous system, and so on, it would seem imprudent to cease or reduce gathering toxicity data on them and establishing limits on human exposures. 

Because of the variation in the incidence of diffraent forms of cancer, it became recognized that environmental, occupational, and lifestyle factors play a major role in cancer risk. As early as 1964, the WHO declared that 75% of all human cancer was affected by extrinsic factors. In 1965, Ihe Intranational Agency for Research on Cancer (lARC) was created to focus on human cancer and Ihe relationship of humans to their environment. 

Fowler BA, Yamauchi H, Conner FA and Akkerman M (1993) Cancer risks for humans from exposures to the semiconductor metals. Scand J Work Environ Health 19 101-103. Gottschling BC, Maronpot RR, Hailey JR, Peddada S, Monnmaw CR, Klaunig and Nyska A (2001) The role of oxidative stress in indium phosphide-induced lung carcinogenesis in rats. Toxicol Sci 64 28-40. 

Susan H. Benoff was formerly director of the Fertihty Research Laboratories of the Feinstein Institute for Medical Research. She was also an associate professor in the Department of Obstetrics and Gynecology of New York University School of Medicine and director of the Molecular Biology Laboratories, Division of Human Reproduction, in the Department of Obstetrics and Gynecology of North Shore University Hospital. Her research interests were in male infertility and testicular cancer with emphasis on the role that environmental exposure to heavy metals and compounds with hormone-like activity may play in the causes of these disorders. She has been an active member of the American Society for Reproductive Medicine, most recently serving as chair of the Environment and Reproduction Special Interest Group. She is also on the Board of Di-... 

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