Ethylenediaminetetraacetic acid calcium disodium chelate

Synonyms calcium disodium edetate calcium disodium ethylenediaminetetraacetate calcium disodium (ethylene-dinitrilo)tetraacetate E385 edathamil calcium disodium edetic acid calcium disodium salt EDTA calcium ethylene-diaminetetraacetic acid calcium disodium chelate [(ethyl-enedinitrilo)tetraacetato]calciate(2-) disodium sodium calciumedetate Nersene CA. 

Ethylenediaminetetraacetic acid (Figure 57-2) is an efficient chelator of many divalent and trivalent metals in vitro. To prevent potentially life-threatening depletion of calcium, the drug should be administered only as the calcium disodium salt. 

Chelation therapy is usually the treatment of choice. Both CaNai-EDTA (calcium disodium salt of ethylenediaminetetraacetic acid) and British Antilewisite compound (BAL 2,3-dimercaptopropanol) are commonly used to remove lead from the body. Both are administered via intramuscular injection. BAL binds lead to sulfhydral groups and chelates metal from both inside and outside the cellular space. Lead removal through the bile and urine is increased within 30 min of administration. BAL is the common choice when there is known toxicity to the kidney, but it is contraindicated if there is liver failure or glucose-6-phosphate dehydrogenase deficiency. BAL treatment has produced a number of adverse reactions, including nausea, vomiting, tachycardia, and fever. 

Ethylenediaminetetraacetic acid (EDTA) is a polycarboxylic acid chelator its sodium salt (edetate disodium, Na EDTA), and a number of closely related compounds chelate many divalent and triva-lent metals. The cation used to make a water-soluble salt of EDTA has an important role in the toxicity of the chelator. Na EDTA causes hypocalcemic tetany. However, edetate calcium disodium (CaNa EDTA) can be used for treatment of poisoning by metals that have higher affinity for the chelating agent than does Ca +. 

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