2,3,7,8-Tetrachlorodibenzo-para-dioxin

NB There is also conclusive evidence that this agent (tamoxifen) reduces the risk of contralateral breast cancer) 2,3,7,8-Tetrachlorodibenzo-para-dioxin [1746-01-6] (Vol. 69 1997)... 

Organohalogen compounds are of serious concern also as contaminants. The most feared material in this category is dioxin (2,3,7,8-tetrachlorodibenzo-para-dioxin, TCDD) that has already caused several catastrophes and has even been detected in effluent and sludge from paper mills that use chlorine bleach and also in... 

From October 1982 to October 1983, the Emergency Planning and Response Branch of Region 7 of the United States Environmental Protection Agency and its contractors collected approximately 8,000 environmental samples for analysis of 2, 3, 7, 8-tetrachlorodibenzo-para-dioxin... 

In mammals, phenobarbital and phenytoin increase serum ceruloplasmin concentrations (Aaseth and Norseth 1986). Chronic copper poisoning in sheep is exacerbated when diets contain heliotrope plants (Heliotropium sp., Echium spp., Senecio sp.). Aggravated effects of the heliotrope plants include reduced survival and a twofold to threefold increase in liver and kidney copper concentrations when compared to control animals fed copper without heliotropes (Howell et al. 1991). Rats given acutely toxic doses of 2,3,7,8-tetrachlorodibenzo-para-dioxin had elevated concentrations of copper in liver and kidney because of impaired biliary excretion of copper (Elsenhans et al. 1991). Morphine increases copper concentrations in the central nervous system of rats, and dithiocarbam-ates inhibit biliary excretion (Aaseth and Norseth 1986). In human patients, urinary excretion of copper is increased after treatment with D-penicillamine, calcium disodium EDTA, or calcium trisodium diethylenetriamine penta acetic acid (Flora 1991). 

Vos, J.G. 1978. 2,3,7,8-Tetrachlorodibenzo-para-dioxin effects and mechanisms. Pages 165-176 in C. Ramel (ed.). Chlorinated Phenoxy Acids and Their Dioxins. Ecol. Bull. (Stockholm) 27. 

Precautions for Safe Handling of 2,3,7,8- Tetrachlorodibenzo-para-Dioxin (TCDD) in the Laboratory Dow Chemical 1978. 

Bertazzi PA, Pesatori AC, Consonni D, et al. 1993. Cancer incidence in a population accidentally exposed to 2,3,7,8-tetrachlorodibenzo-para-dioxin. Epidemiol 4 398-406. 

FehringerNV, Walter SM, Kozara RJ, et al. 1985. Survey of 2,3,7,8-tetrachlorodibenzo-para-dioxin in fish from the Great Lakes and selected Michigan rivers. J Agric Food Chem 33 626-630. 

Ideo G, Bellati G, Bellobuono A, et al. 1982. Increased urinary D-glucaric acid excretion by children living in an area polluted with 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD). Clin Chim Acta 120 273-283. 

Dioxins are a family of heterocyclic hydrocarbons, mostly poisonous chemical by-products of the manufacture of certain herbicides and bactericides. The most toxic are polychlorinated dibenzo-p-dioxins (CDDs) and dibenzo-furans (CDFs, also called dioxins) [514,515]. Amongst the most dangerous are the isomers of the 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) and 2,3,7,8-tetrachlorodibenzo-furan (TCDF). The former occurs in small amounts in some herbicides and defoliants, including the so-called Agent Orange (a highly toxic herbicide sprayed as a defoliant in chemical warfare) [466]. 

Lower The isomer 2,3,7,8-tetrachlorodibenzo-para-dioxin (2,3,7,8-TCDD). 

Tetrachlorodibenzo-para-dioxin (TCDD) Tetracycline (internal use)... 

Dioxin is a term used to describe a large group of chemical compounds having a similar basic structure. The most common subgroup of dioxin compounds (of which there are 75 different varieties) comprises those which include chlorine atoms. A few are toxic the most toxic is 2,3,7,8-tetrachlorodibenzo(para) dioxin (2,3,7,8-TCDD). There are also 135 polychlorinated dibenzofuran corrtpotmds, known as furans. ... 

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