Calcitonin Thyroid carcinoma

S. Hoegerle, C. Altehoefer, N. Ghanem, I. Brink, E. Moser, E. Nitzsche, F-DOPA positron emission tomography for tumor detection in patients with medullary thyroid carcinoma and elevated calcitonin levels, Eur. J. Nucl. Med. 28(1) (2001) 64-71. [Pg.196]

Vitale G, Ciccarelli A, Caraglia M, Galderisi M, Rossi R, Del Prete S, Abbruzzese A, Lupoli G. Comparison of two provocative tests for calcitonin in medullary thyroid carcinoma omeprazole vs pentagastrin. Clin Chem 2002 48(9) 1505-10. [Pg.2773]

Takami, H. et al. (1992) Calcitonin gene-related peptide as a tumour marker for medullary thyroid carcinoma. Int. Surg.. 77.181-185. [Pg.274]

Calcitonin is secreted by the parafollicular or C cells, which arise from the neural crest and are distributed throughout the thyroid gland. These cells are included in the APUD (cmine precursor uptake and decarboxylation) family, which explains the association of medullary thyroid carcinoma (a tumor of the C cells) and other tumors of the APUD family in multiple endocrine neoplasia type 2A and -2B (MEN-2A and MEN-2B). Release of calcitonin is stimulated by calcium, and it has been used pharmacologically as an inhibitor of bone resorption. [Pg.1926]

Multiple forms of circulating calcitonin have been reported in normal individuals and patients with medullary thyroid carcinoma (MTC) or nonthyroidal malignancies. Much of the immunoreactive calcitonin generally migrates as larger forms rather than with monomeric calcitonin. A... [Pg.1926]

Barbot N, Calmettes C, Schuffenecker I, Saint-Andre JP. Pentagastrin stimulation test and early diagnosis of medullary thyroid carcinoma using an immunora-diometric assay for calcitonin comparison with genetic screening in hereditary medullary thyroid carcinoma. J Clin Endocrinol Metab 1994 78 114-20. [Pg.1944]

Body JJ, Heath H III. Nonspecific increases in plasma immunoreactive calcitonin in healthy individuals discrimination from medullary thyroid carcinoma by a new extraction technique. Chn Chem 1984 30 511-14. [Pg.1945]

Gharib H, Kao PC, Heath H III. Determination of silica-purified plasma calcitonin for the detection and management of medullary thyroid carcinoma comparison of two provocative tests. Mayo Clin Proc 1987 62 373-8. [Pg.1951]

Goltzman D, Tischler AS. Characterization of the unmunochemical forms of calcitonin released by a medullary thyroid carcinoma in tissue culture. J Clin Invest 1978 61 449-58. [Pg.1951]

Pacini F, FontaneUi M, Fugazzola L, Elisei R, Ehsei R, Romei C, Di Coscio G, et al. Routine measurement of serum calcitonin in nodular thyroid diseases allows the preoperative diagnosis of unsuspected sporadic medullary thyroid carcinoma. J Clin Endocrinol Metab 1994 78 826-9. [Pg.1958]

Perdrisot R, Bigorgne JC, Guhloteau D, Jallet P. Monoclonal immunoradiometric assay of calcitonin improves investigation of famhial medullary thyroid carcinoma, Clin Chem 1990 36 381-3. [Pg.1958]

Rieu M, Lame MC, Richard A, Lissak B, Lissak B, Sambort B, et al. Prevalence of sporadic medullary thyroid carcinoma the importance of routine measurement of serum calcitonin in the diagnosis and evaluation of thyroid nodules. Clin Endocrinol (Oxf) 1995 42 453-60. [Pg.1959]

Rude RK, Matsumoto S, Singer FR. Heterogeneity of immunoreactive calcitonin in extracts of medullary thyroid carcinoma. Miner Electrolyte Metab 1982 7 292-7. [Pg.1960]

Rude RK, Singer FR. Comparison of serum calcitonin levels after a 1-minute calcium injection and after pentagastrin mjection in the diagnosis of medullary thyroid carcinoma. J Clin Endocrinol Metab 1977 44 980-3. [Pg.1960]

Zink A, Blind E> Raue F. Determination of serum calcitonin by immunometric two-site assays in normal subjects and patients with medullary thyroid carcinoma. Eur J Clin Chem Clin Biochem 1992 30 831-5. [Pg.1965]

Loss of the thyroid gland with its calcitonin-producing C cells does not cause osteoporosis, and high levels of calcitonin associated with thyroid carcinoma do not cause osteosclerosis, thick, well mineralized bones distinct from the dense, continuously growing bone that characterizes osteopetrosis (see Sects. 10.2.1 and 10.2.2). These findings indicate that calcitonin does not increase bone deposition, but rather inhibits osteoclast activity... [Pg.172]

Cll. Cunliffe, W. J. et al., Calcitonin-secreting thyroid carcinoma. Lancet II, 63-66 G968). [Pg.416]

Poorly differentiated endocrine neoplasms, depending on the site of origin, may produce characteristic peptide hormones. The group of poorly differentiated neuroendocrine tumors and their hormone production include islet cell tumors (insulin, glucagon, somatostatin, gastrin), pulmonary small cell carcinoma (bombesin in 45% of cases), and medullary thyroid carcinoma (calcitonin). [Pg.226]

The differential diagnosis of carcinoid and atypical carcinoid tumors of the larynx includes paraganglioma, melanoma, and medullary thyroid carcinoma. Paragangliomas are rarely always negative for cyto-keratins and also exhibit the characteristic susten-tacular cell pattern with SlOO protein. Thyroid transcription factor-1 (TTEl) is positive in medullary thyroid carcinoma, as are calcitonin and CEA. Melanomas will typically stain with HMB45 and tyrosinase, both of which are negative in neuroendocrine carcinomas. [Pg.273]

Medullary thyroid carcinomas are positive for calcitonin in more than 95% of cases (Figs. 10.21 and... [Pg.306]

FIGURE 10.22 A, Medullary thyroid carcinoma (EI E stain). B, Immunoperoxidase stain for calcitonin. The tumor cells are strongly positive for calcitonin. [Pg.307]

Zajac JD, Penschow J, Mason T, et al. Identification of calcitonin and calcitonin gene related peptide messenger RNA in medullary thyroid carcinoma by hybridization histochemistry. J Clin Endocrinol Metab. 1986 62 1037-1043. [Pg.333]

Steenbergh PH, Hoppener JW, Zandberg J, et al. Calcitonin gene related peptide coding sequence is conserved in the human genome and is expressed in medullary thyroid carcinoma. J Clin Endocrinol Metab. 1984 59 358-360. [Pg.333]

DeLellis RA, Rule AH, Spilet I, et al. Calcitonin and catcinoem-btyonic antigen as tumot matkets in medullary thyroid carcinoma. Am J Clin Pathol. 1978 70 587-594. [Pg.333]

Mendelsohn G, Wills Jt SA, Baylin SB. Relationship of tissue catcinoembtyonic antigen and calcitonin to tumot virulence in medullary thyroid carcinoma An immunohistochemical study in eatly, localized and virulent disseminated stages of disease. Cancer. 1984 54 657-662. [Pg.333]

DeBustros, A. Lee, R. Y. Compton, D. Tsong, T. Y. Baylin, S. B. Nelkin, B. D. Different cis-acting DNA elements regulate expression of the human calcitonin gene in cultured lines of lung carcinoma and medullary thyroid carcinomas. Mol. Cell Biol. 10, 1773-1778. [Pg.567]

P.M. et al. (2001) Circulating calcitonin and carcinoembryonic antigen m-RNA detected by RT-PCR as tumor markers in medullary thyroid carcinoma. Br J Cancer, 85, 154-1550. [Pg.270]

Schott M, Feldkamp J, Klucken M, Kobbe G, Scherbaum WA, Seissler J. Calcitonin-specific antitumor immunity in medullary thyroid carcinoma following dendritic cell vaccination. Cancer Immunol Immunother 2002 51 663—668. [Pg.483]

We have studied a patient with thyroid carcinoma and renal hypouricemia that could be attributed to increased calcitonin secretion. [Pg.212]

Fig. 34.3. FDOPA images (CT on the left, fused images in the middle, and whole-body PET [MIP] on the right) of a patient after thyroidectomy for medullary thyroid carcinoma (6 years ago), actually presenting with elevated calcitonin levels. PET shows pathologically increased uptake in a normal sized cervical lymph node (upper row) and in two lesions within the thyroid bed Surgery confirmed local recurrence of MTC and lymph node metastasis in this patient. Calcitonin levels normalized following surgery...

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