2-Bromo-2-nitropropane-l ,3-diol

B, 2-phenoxyethanol C, chlorbutol (trichlonw-butanol) D, Bronopol (2-bromo-2-nitropropan-l,3-diol). 

Mercuric chloride, other mercury-containing antibacterials and silver will inhibit enzymes in the membrane, and for that matter in the cytoplasm, which contain thiol, -SH, groups. A similar achon is shown by 2-bromo-2-nitropropan-l,3-diol (bronopol) and iso-thiazolones. Under appropriate condihons the toxic action on cell thiol groups may be reversed by addition of an extrinsic thiol compound, for example cysteine or thioglycollic aeid (see also Chapters 12 and 23). 

Bromo-2-nitropropane-l,3-diol, latex auxiliary. Bound Rubber... 

This paper will address some of these problem areas and consider options for the mineral slurry producer based on currently available technologies, focusing in particular on Bronopol (Myacide AS 2-bromo-2-nitropropane-l,3-diol). 

Slurries 1, 3, 4 and 8 show the new liquid blend, l,2-dibromo-2,4-dicyanobutane + 2-bromo-2-nitropropane-l,3-diol, as being the most effective product, while the 2-bromo-2-nitropropane-l,3-diol was most effective in slurries 2, 5, 6 and 7. In order to appreciate the advantages of this new blend over the products tested, the observations from the study of each of the products are listed in the discussion. 

The 2-bromo-2-nitropropane-l,3-diol was effective in controlling the Methylobacterium sp. but, due its stability issues in pigment slurries, it is recommended as the second product of choice. 

V-Nitrosodiethanolamine is formed by the action of nitrosating agents (nitrites 2-bromo-2-nitropropane-l,3-diol nitrogen oxides) on diethanolamine and triethanolamine (Schmeltz Wenger, 1979 Hofimann etal, 1982 Budavari, 1998). The rate of formation of A-nitrosodiethanolamine in aqueous solutions of ethanolamines is pH-, temperature- and time-dependent. The reaction was originally thought to occur only... 

Okieimen, EE. Akintola, E.O. (1985) Contamination of daily and tobacco products by trace quantities of nitrosodiethanolamine (NDELA). Bull, environ. Contam. Toxicol., 35,466 70 Ong, J.T.H. Rutherford, B.S. (1980) Some factors aflecting the rate of V-nitrosodiethanol-amine formation from 2-bromo-2-nitropropane-l,3-diol and ethanolamines. J. Soc. Cosmet. Chem., 31, 153-159... 

Bromo-2-nitropropane-l,3-diol. Organo-bromine group. General-purpose microbiocide, slimicide, and aerobic/anaerobic bactericide. A benefit... 

Under certain circumstances, formation of new substances can be seen during manufacturing, storage or use. Formation of different nitrosamines was found in products with dialkanolamines together with some nitrosating agents. 2-Bromo-2-nitropropane-l,3-diol and 5-bromo-5-nitro-l,3-dioxane are two, but not the only, examples of such substances. This formation of nitrosamines is important to avoid or minimize, as many different nitrosamines are shown to be carcinogenic is animals. 

SYNS 2-BROMO-2-NITROPANE-1.3-DIOL 2-BROMO-2-NITROPROPAN-l,3-DIOL p-BROMO-P-NITROTRIMETHYLENEGLYCOL BRONOCOT BRONOPOL BRONOSOL... 

Choudry K, Beck MH, Muston HL. Allergic contact dermatitis from 2-bromo-2-nitropropane-l,3-diol in Metrogel. Contact Dermatitis 2002 46(1) 60-1. 

BASE Corp. Technical literature Bronopol products, 2000. Maibach HI. Dermal sensitization potential of 2-bromo-2-nltropropane-l,3-dlol (bronopol). Contact Dermatitis 1977 3 99. Elder RL. Final report on the safety assessment for 2-bromo-2-nltropropane-l,3-dlol. J Environ Pathol Toxicol 1980 4 47-61. Storrs FJ, Bell DE. Allergic contact dermatitis to 2-bromo-2-nitropropane-l,3-diol in a hydrophilic ointment. J Am Acad Dermatol 1983 8 157-170. 

Bronopol (2-bromo-2-nitropropan-l,3-diol). Typical in-use concentration 0.01-0.1%. It has a broad spectrum of antibacterial activity, including Pseudomonas species. The main limitation on the use of bronopol is that when exposed to light at... 

Of the halogen nitro alkane compound, bronopol (2-bromo-2-nitropropan-l,3-diol, 1), proved to be also in agricultural use an active substance with good specific bacterostatic action. Bronopol is a compound with wide antimicrobial action, of low toxicity to mammals (Croshaw et al.. 1964). This compound was originally used in the cosmetic and pharmaceutical industries. Its acute oral lDjq is 180-400 mg/kg for rats. Bronopol is rapidly excreted in the urine (Naito et al., 1974). 

Many other preservatives can be used, such as p-hydroxy benzoic acid, sorbic acid, and hydroxy quinoline sulfate. Another bactericide used is 2-bromo-2-nitropropane-l,3-diol (Bronopol). 

Rubber gloves-ultrasonic bath extract (Bruze et al. 1992) 2-Bromo-2-nitropropane-l,3-diol 0.25% pet (Rietschel and Fowler 1995)... 

Ruegg, U. T. and Rudinger, J., 1977. Reductive cleavage of cystine disulfides with tributylphosphine. Methods in Enzymology 47, 111-116. Shepherd, J. A., Waigh, R. D. and Gilbert, P., 1988. Antibacterial action of 2-bromo-2-nitropropane-l,3-diol (Bronopol). Antimicrob. Agents... 

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