2-Bromo-2-nitropropane-l,3-diol Bronopol

Mercuric chloride, other mercury-containing antibacterials and silver will inhibit enzymes in the membrane, and for that matter in the cytoplasm, which contain thiol, -SH, groups. A similar achon is shown by 2-bromo-2-nitropropan-l,3-diol (bronopol) and iso-thiazolones. Under appropriate condihons the toxic action on cell thiol groups may be reversed by addition of an extrinsic thiol compound, for example cysteine or thioglycollic aeid (see also Chapters 12 and 23). 

Many other preservatives can be used, such as p-hydroxy benzoic acid, sorbic acid, and hydroxy quinoline sulfate. Another bactericide used is 2-bromo-2-nitropropane-l,3-diol (Bronopol). 

Ruegg, U. T. and Rudinger, J., 1977. Reductive cleavage of cystine disulfides with tributylphosphine. Methods in Enzymology 47, 111-116. Shepherd, J. A., Waigh, R. D. and Gilbert, P., 1988. Antibacterial action of 2-bromo-2-nitropropane-l,3-diol (Bronopol). Antimicrob. Agents... 

Bromo-2-nitropropane-l,3-diol (Bronopol - Figure 10) [II, 17.14] was previously classified as a formaldehyde donor (Paulus, 1993) as it is possible to demonstrate release of up to 30% of it s theoretical content in dilute solution at alkaline pH. However, the amount of formaldehyde theoretically able to be released from Bronopol is far too low to account for its efficacy, e.g. 25 ppm from 200 ppm of Bronopol, when levels of formaldehyde in the range 500 - 1,000 ppm are necessary. Therefore Scheid (2002) believed that any formaldehyde evolved plays little or no part in its biocidal activity. 

This paper will address some of these problem areas and consider options for the mineral slurry producer based on currently available technologies, focusing in particular on Bronopol (Myacide AS 2-bromo-2-nitropropane-l,3-diol). 

Bronopol (2-bromo-2-nitropropan-l,3-diol). Typical in-use concentration 0.01-0.1%. It has a broad spectrum of antibacterial activity, including Pseudomonas species. The main limitation on the use of bronopol is that when exposed to light at... 

Of the halogen nitro alkane compound, bronopol (2-bromo-2-nitropropan-l,3-diol, 1), proved to be also in agricultural use an active substance with good specific bacterostatic action. Bronopol is a compound with wide antimicrobial action, of low toxicity to mammals (Croshaw et al.. 1964). This compound was originally used in the cosmetic and pharmaceutical industries. Its acute oral lDjq is 180-400 mg/kg for rats. Bronopol is rapidly excreted in the urine (Naito et al., 1974). 

Procaine hydrochloride Unicaine-B 200-087-7 2,4-Dintrophenol 200-091-9 L-Hydroxyproline 200-123-1 Urethane 200-125-2 m-Aminophenol HCI Rodol EGC 200-143-0 Bioban BNPD Bioban BNPD-40 Bioban BP Pharma Bioban BP Pharma 30 Bioban BP-Plus 2-Bromo-2-nitropropane-1,3-diol Bronopol ... 

BASE Corp. Technical literature Bronopol products, 2000. Maibach HI. Dermal sensitization potential of 2-bromo-2-nltropropane-l,3-dlol (bronopol). Contact Dermatitis 1977 3 99. Elder RL. Final report on the safety assessment for 2-bromo-2-nltropropane-l,3-dlol. J Environ Pathol Toxicol 1980 4 47-61. Storrs FJ, Bell DE. Allergic contact dermatitis to 2-bromo-2-nitropropane-l,3-diol in a hydrophilic ointment. J Am Acad Dermatol 1983 8 157-170. 

SYNS 2-BROMO-2-NITROPANE-1.3-DIOL 2-BROMO-2-NITROPROPAN-l,3-DIOL p-BROMO-P-NITROTRIMETHYLENEGLYCOL BRONOCOT BRONOPOL BRONOSOL... 

B, 2-phenoxyethanol C, chlorbutol (trichlonw-butanol) D, Bronopol (2-bromo-2-nitropropan-l,3-diol). 

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