Metastasis breast cancer

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We tested combiBUILD by using it to help design inhibitors for cathepsin D. Cathepsin D is an aspartyl protease whose structure has been solved with the inhibitor pepstatin. It is implicated in several disease processes including Alzheimer s amyloid plaque formation and breast cancer metastasis. Our goal was to design a small library of 1000 compounds of possible inhibitors to Cathepsin D. 

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Evidence for Cross-Talk Between CXCR4 and IGF-1 R Signal Transduction in Breast Cancer Metastasis... 

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