Breast promoter

Prolactin (PRL) Anterior Pituitary (Lactotroph) 198 aa (23 kDa) 6p22.2-q21.3 Stimulates growth and protein synthesis in breast promotes milk secretion during lactation. Primarily inhibited by PIH (dopamine) stimulated by PRF and TRH. 

The human PR exists as two functionally distinct isoforms PRA and PRB transcribed from two promoters from a single gene. PRA lacks the N-terminal 164 aa and is a 769 aa protein. PRB functions as a transcriptional activator in most cell and promoter contexts. In contrast, PRA is transcriptionally inactive and functions as a strong ligand-dependent transdominant repressor of SHR transcriptional activity. Different cofactor interactions were demonstrated for PRA and PRB, probably due to an inhibitory domain within the first 140 aa of PRA, which is masked in PRB. Both PR isoforms however, repress estradiol-induced ER activity when liganded. Several other mRNA isoforms are present in PR-positive tissues such as breast cancer with unknown clinical significance. 

The uses of the various anabolic steroids include management of anemia of renal insufficiency, control of metastatic breast cancer in women, and promotion of weight gain in those with weight loss after surgery, trauma, or infections. Stanozolol is used prophylactically... 

The estrogens are secreted by the ovarian follicle and in smaller amounts by the adrenal cortex. Estrogens are important in the development and maintenance of the female reproductive system and the primary and secondary sex characteristics. At puberty, they promote growth and development of the vagina, uterus, fallopian tubes, and breasts. They also affect the release of pituitary gonadotropins (see Chap. 50). 

Other actions of estrogen include fluid retention, protein anabolism, thinning of the cervical mucus, and the inhibition or facilitation of ovulation. Estrogens contribute to the conservation of calcium and phosphorus, the growth of pubic and axillary hair, and pigmentation of the breast nipples and genitals. Estrogens also stimulate contraction of the fallopian tubes (which promotes movement of the ovum), modify the physical and chemical properties of the cervical mucus, and restore the endometrium after menstruation. 

The posterior pituitary is innervated by direct nervous stimulation from the hypothalamus, resulting in the release of specific hormones. The hypothalamus synthesizes two hormones, oxytocin and vasopressin. These hormones are stored in and released from the posterior pituitary lobe. Oxytocin exerts two actions (1) it promotes uterine contractions during labor, and (2) it contracts the smooth muscles in the breast to stimulate the release of milk from the mammary gland during lactation. Vasopressin is an antidiuretic hormone (ADH) essential for proper fluid and electrolyte balance in the body. Specifically, vasopressin increases the permeability of the distal convoluted tubules and collecting ducts of the nephrons to water. This causes the kidney to excrete less water in the urine. Consequently, the urine becomes more concentrated as water is conserved. 

Docetaxel, another taxane, binds to tubulin to promote microtubule assembly. The pharmacokinetics of docetaxel are best described by a three-compartment model, with an a half-life of 0.08 hours, a 3 half-life of 1.6 to 1.8 hours, and a terminal half-life of 65 to 73 hours.14 Docetaxel has activity in the treatment of breast, non-small cell lung, prostate, bladder, esophageal, stomach, ovary, and head and neck cancers. Dexamethasone, 8 mg twice daily for 3 days starting the day before treatment, is used to prevent the fluid retention syndrome associated with docetaxel and possible hypersensitivity reactions. The fluid... 

Bachelder RE, Wendt MA, Mercurio AM. Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res 2002 62(24) 7203-7206. 

Helbig G, Christopherson KW, Bhat-Nakshatri P, et al. NF-kB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J Biol Chem 2003 278 21631-21638. 

The drug consists of the dried berries that are prescribed for headache, catarrh, watery eyes, and are used to promote beard growth. In Cambodia, Laos, and Vietnam, the berries are used to treat conjunctivis, dropsy, toothache, and as a remedy for swollen breast. In Malaysia, the leaves are used to assuage headache externally, and internally are used to treat tuberculosis and fever. 

King-Batoon et al. have found that the physiological concentrations of lycopene (2pM) partially demethylated the promoter for GSTP1 and restored its expression in the breast cancer cell line MDA-MB-468, but RAR0 was not demethylated. However, lycopene did induce the demethylation of RARp in MCF10A fibrocystic cells (King-Batoon et al. 2008). Genistein, in this study, was less active compared to lycopene. 

Clark, A.S., West, K., Streicher, S., and Dennis, P.A. 2002. Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells Mol Cancer Ther 1 707-717. 

The IBIS-I study was promoted by the UK Coordinating Committee for Cancer Research and supported by the Imperial Cancer Research Fund. A group of 7152 high-risk women were selected according to criteria related to familial cases of breast cancer, previous atypical biopsies, and parity. The most important group was that of women with two or more first- or second-degree relatives with breast cancer. For this group the yearly frequency of breast cancer, in the absence of any intervention, was calculated to be 7.50 per 1000 women. This proved to be accurate since the actual frequency in the placebo... 

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