Bladder cancer gemcitabine

Gemcitabine Inhibits DNA synthesis and repair inhibits ribonucleotide reductase with reduced formation of dNTPs incorporation of gemcitabine triphosphate into DNA resulting in inhibition of DNA synthesis and function Pancreatic cancer, bladder cancer, breast cancer, non-small cell lung cancer, ovarian cancer, non-Hodgkin s lymphoma, soft tissue sarcoma Nausea, vomiting, diarrhea, myelosuppression... 

Gemcitabine was initially approved for use in pancreatic cancer but is now widely used in the treatment of non-small cell lung cancer and bladder cancer. Myelosuppression is the principal dose-limiting toxicity. 

Larotaxel (XRP-9881, RPR 109881A) 59 (Sanofi-Aventis) is undergoing Phase III trials in patients with advanced pancreatic cancer who had been previously treated with gemcitabine, as well as in combination with cisplatin to treat locally advanced/metastatic urothelial tract or bladder cancer.124 A Phase III trial for the treatment of advanced breast cancer has been completed. Larotaxel 59129>130 js a semi-synthetic derivative of 10-deacetyl baccatin III with a docetaxel-like side chain that has a low affinity for the P-glycoprotein drug efflux pump, an efflux mechanism that diminishes the effectiveness of the marketed drugs paclitaxel 60 and docetaxel. Importantly, this low affinity should enable larotaxel 59 to be effective in tumours resistant to paclitaxel 60... 

Gemcitabine (Gemzar) Pancreatic cancer NSCLC breast cancer head and neck cancer bladder cancer testicular cancer ovarian cancers, HD... 

An in vitro study using human bladder cancer cells found that both gemcitabine and epirubicin alone exerted a cytotoxic effect but the efficacy of the combination of epirubicin and gemcitabine depended on the schedule... 

Shelley M, Cleves A, Wilt TJ, Mason M. Gemcitabine for unresectable, locally advanced or metastatic bladder cancer. Cochrane Database Syst Rev 2011 (4) CD008976. 

Gemcitabine is an S-phase-specific pyrimidine nucleoside analogue of deoxycytidine (2, 2 -difluorodeoxycytidine) that is structurally similar to cytosine arabinoside. It has been used to treat metastatic urothelial carcinoma of the bladder, pancreatic cancer, and some other solid tumors. 

Birlik M, Akar S, Tuzel E, Onen F, Ozer E, Manisali M, Kirkali Z, Akkoc N. Gemcitabine-induced vascuhtis in advanced transitional cell carcinoma of the bladder. 1 Cancer Res Clin Oncol 2004 130(2) 122-5. 

Gemcitabine for non-small cell lung cancer, pancreatic, bladder and breast cancer 12,950 Temozolamide as second line treatment for malignant glioma (brain cancer) 35,000... 

Gemcitabine (2, 2 difluorodeoxycytidine dFdC), a di-fluoro analog of deoxycytidine, has become an important drug for patients with metastatic pancreatic cancer nonsmall-cell lung cancer and ovarian, bladder, esophageal, and head and neck cancer. 

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